Sentences with phrase «normal cells do»

It's just that normal cells don't normally grow.

Potential therapies targeting this synthetic lethal target will have dramatically reduced toxicity since normal cells do not rely on these genes.

Christofk studies the genes and proteins behind the way cancer cells use sugars to live and grow, which is different from how normal cells do.

The limitation may be that normal cells do not produce active telomerase, which can rebuild the telomeres and keep cells from becoming senescent.

«Because normal cells don't acquire super-enhancers on these master regulators, the agent had a profound impact on neuroblastoma tissue but not on normal tissue,» says the study's senior author, Rani George, MD, PhD, of Dana - Farber / Boston Children's.

In addition, cells under stress often behave differently than normal cells do, a huge stumbling block for scientists trying to draw connections between their experiments and the natural world.

Gabriela Cabral explains: «When a stem cell divides, it doesn't produce two identical daughter cells as normal cells do.

Not exact matches

Since PSMA's limited on normal cells, the therapy should hammer away at tumors while letting healthy tissues do their job.

While the entity generated by deleting or disabling early embryonic genes would produce only an unorganized collection of stem cells, it would do so after a period of what appears to be relatively normal development.

Catholics take it as literal... The body is certainly not resurrected in terms of the cell, the protoplasm, the DNA... that certainly doesn't happen any more than the wafer turns into [the literal body of Christ]... in the sense in which any normal use of the English language would understand.

For the first time they were able to show that the stem cells accumulate in large quantities and do not die like «normal» cells.

It's normal for the red blood cells to break down, although the bilirubin formed doesn't normally cause jaundice because the liver will metabolize it and then get rid of it in the gut.

It is normal for old red blood cells to break down, but the bilirubin formed does not usually cause jaundice because the liver metabolizes it and gets rid of it into the gut.

Does this mean that everyone born before cell phones and / or TV was invented and was breastfed was normal?

It is normal for red blood cells to break down, but the bilirubin formed does not

It is normal for red blood cells to break down, but the bilirubin formed does not usually cause jaundice because the liver metabolizes it and gets rid of it into the gut.

According to Chan, neoantigens have two advantages: First, they look very foreign to the immune system and second, they don't appear in normal cells.

«Mitalipov clearly has very high efficiency, and the cells are highly normal, and that's what iPS cells don't yet deliver,» says Chris Mason of University College London.

Normal mice saw benefits, too: Muscles and pancreas cells healed better in middle - aged mice that got rejuvenation treatments than in mice that did not.

Goadsby doesn't know yet if the brain cells involved are bigger than those in normal patients or if there are simply more of them; that would require the dissection of a brain.

They found — as they did in the 2016 study — that when these cells expressed SOD1 mutants that predominantly form trimers, the cells died much more quickly than control cells containing normal SOD1.

HIV exploits the normal version of this protein to enter cells, but can not do the same with the mutated protein.

«This is the first demonstration that cells carrying a genetic disease are capable of spreading into the normal mammalian brain and lead to the manifestation of behavioral abnormalities associated with the disease,» says Francesca Cicchetti, professor at the Université Laval Faculty of Medecine and researcher at Centre de recherche du CHU de Québec - Université Laval.

But the compound was not able to do so in normal skin cells.

Kingsley's team had no idea what the normal gene does, but a team at the University of Tokyo had recently identified the genetic defect behind a similar mouse disease — and determined that its protein product normally generates pyrophosphate on the outside of joint cells to keep the joints scale - free.

In normal bone development, the shaft matures and ceases growth (cell division) long before the ends do.

Test tube experiments showed that white blood cells with the mutation responded more strongly to Il - 4 than did normal cells.

However, when the researchers knocked out SIRT1 in endothelial cells of 10 - month - old mice, then put them on a four - week treadmill running program, they found that the exercise did not produce the same gains seen in normal 10 - month - old mice on the same training plan.

A virus works with the cell machinery, so it's hard to come up with a drug that doesn't interfere with the cell's normal function.

The TERT promoter mutation does not generate enough telomerase to immortalize the pre-cancerous cells, but does delay normal cellular aging, Hockemeyer said, allowing more time for additional changes that turns telomerase up.

Researchers found that CML stem cells accumulate significantly higher levels of certain dipeptide species than do normal hematopoietic stem cells.

Normal cells, therefore, do not incorporate RNA nanoparticles, reducing the risk of toxic effects.

Normal human colon cells, kidney cells, lung cancer cells and two strains of colon cancer cells didn't respond to the bacteria.

«You do kill a few normal cells with the drugs, but you do that anyway with surgery,» she says.

As the researchers suspected, the Werner cells didn't divide and replicate as many times as normal cells.

I found that culturing cardiac valve cells on synthetic hydrogels preserves their normal properties better than the traditional plastic plates do, and I discovered a signaling pathway connecting the stiffness of the supporting scaffold to the cells» cytoskeletal structure.

The tumor suppressor p53 does all it can to prevent oncogenes from transforming normal cells into tumor cells by killing defective cells or causing them to become inactive.

In cells grown on flat culture dishes, the expression of thousands of genes didn't match up with their normal patterns, explaining why the cells from those dishes had been unable to generate new hair follicles.

In 1924, Otto Warburg showed that cancer cells produced far more energy from glycolysis than did normal cells.

Not only did the normal mice develop plaques, but also a pathology similar to «tangles» — twisted protein strands that form inside brain cells, disrupting their function and eventually killing them from the inside - out.

In normal development, all cells turn off genes they don't need, often by attaching a chemical methyl group to the DNA, a process called methylation.

She discovered that the protective cells of autistic youngsters mount a less vigorous defense against bacterial compounds than do those of normal children.

The team learned that the cells from the group of obese patients suffering from type 2 diabetes had been reprogrammed and therefore did not function like normal, healthy fat cells.

When they exposed these mice to the cold, the animals developed far fewer beige fat cells than did normal animals, suggesting that macrophages were key to browning of white fat.

When they restored normal nitric oxide levels by having mice breathe in the short - lived gas — as patients have done in clinical trials — cell adhesion did not increase when oxygen levels decreased.

Exposure to low - oxygen air sends EPO levels soaring in normal mice, but these conditions did not induce a rise in the hormone in the animals without HIF - 1α, the researchers report in the 18 April issue of Cell.

Bone marrow from the p16 - deficient mice made 3 times as many blood - forming stem cells as bone marrow from the normal mice did.

Importantly, normal cells in the body do not have SETD2 mutations, so these effects of WEE1 inhibition are potentially very selective to cancer cells.»

Normal resting cells do not express CD25.

We still don't know if [the cells created by Thomson and Yamanaka] are going to do all the same things as normal embryo - derived stem cells,» says ACT Chief Scientific Officer Robert Lanza.