Sentences with phrase «normal cellular genes»

With these tools, Verma is revealing how the aberrant expression of normal cellular genes can causes tumors.

Not exact matches

To account for the remarkable similarity between retrovirus oncogenes and their normal cellular kin, most virologists have settled on the idea that retrovirus oncogenes are copies of cellular genes.

We all have ras genes, which make proteins that are vital to normal cellular function.

By comparing the gene expression patterns of normal beta cells and insulin - producing cells derived from alpha cells, the researchers confirmed nearly complete cellular reprogramming.

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»

«Following on the work of TSRI Professor Ardem Patapoutian, who has identified many of the genes that endow these neurons with selective responses to temperature, pain and pressure, we have found a way to produce induced sensory neurons from humans where these genes can be expressed in their «normal» cellular environment,» said Associate Professor Kristin K. Baldwin, an investigator in TSRI's Dorris Neuroscience Center.

The cells, which also expressed lower levels of genes involved in normal cellular metabolism, were evenly distributed throughout the liver's lobules.

Once the gene was in place, the normal cellular machinery produced it just like any other enzyme.

However, this cellular intervention alters the normal expression of hypophosphorylated retinoblastoma (RB) protein needed for the expression of genes involved in cell functions [3] and, therefore, results in an abnormal cell.

Unlike the case of most gene therapies that are intended to permanently alter their target cells, however, Oisín's senoablative genetic constructs will not be inserted permanently into the patient's genome: instead, its genetic payload will be expressed temporarily from the main body of the cell, following which the construct will be passively degraded by normal cellular metabolism.

That way, even if the original genes in the mitochondrial are deleted, the backup copies will be able to supply the proteins needed to keep normal energy production going, allowing the cellular power plants to continue humming along normally and preventing them from entering into the toxic, mutant metabolic state.

«This suggests that two different gene expression programs may exist; one for normal cellular activity and one for regeneration,» explains Stewart.

This DNA becomes damaged in the course of normal cellular processes, and certain forms of mitochondrial DNA damage - to the thirteen genes needed for oxidative phosphorylation - produce malfunctioning mitochondria that can overtake their cells, either by replicating more readily or being more resistant to quality control mechanisms.

HDAC inhibitors assist in «switching on» the silenced genes and repair normal cellular function.

Enzymes are essential for energy production, synthesis of biological molecules, gene repair and replication, maintenance of cellular and tissue structural integrity, and normal physiological function.

Scientists believe sulforaphane's benefits are related to improved DNA methylation, which is crucial for normal cellular function and proper gene expression, especially in the easily damaged inner lining of the arteries known as the endothelium.