Not exact matches
It is unclear how the entire body is affected because Spector looked only at telomeres, nucleotides on the
ends of
chromosomes that slowly erode as cells copy themselves during
normal aging.
Scientists discovered that a particular class of
normal breast precursor cells have extremely short
chromosome ends (known as telomeres).
Their studies revealed that a subset of
normal breast precursor cells, called luminal progenitors, have dangerously short telomeres and display a correspondingly high level DNA damage response localized at their
chromosome ends.
When researchers took a close look at the cells of Dolly, the cloned sheep, they found that her telomeres, the caps on the
ends of the
chromosomes, were shorter than
normal.
LA JOLLA, CA — Rapidly dividing cancer cells are skilled at patching up damage that would stop
normal cells in their tracks, including wear and tear of telomeres, the protective caps at the
end of each
chromosome.
Scientists have glimpsed the three - dimensional structure of a protein that protects the
ends of human
chromosomes, a function that is essential for
normal cell division and survival.
This exhaustion of proliferative potential, called senescence, can be triggered when telomeres — the
ends of linear
chromosomes - can not fulfil their
normal protective functions.