Sentences with phrase «normal copy»

After all, tests in many laboratories showed that providing normal copies of the gene should enable patients to make healthy copies of the protein specified by the gene.

The idea was simple: abnormal copies of a gene are responsible for a disease, so let's provide the cells with normal copies!

As they age, they are at higher risk of developing mutations in the remaining normal copy of the gene.

For starters, color laser technology produces great results, even when printing on normal copy paper.

The dog has 2 normal copies of the gene.

If one copy of one of these genes from one parent is already mutated at birth, the second normal copy from the other parent often can compensate for the defect.

Starting in 1983, Pereira - Smith and Smith published a series of studies establishing that senescence is a dominant genetic trait involving several as - yet - unknown genes (or groups of genes): In the simplest scenario, a cell enters cellular limbo only if it carries at least a single normal copy of each of the genes.

But oddly enough, the team found that a large percentage of the resulting mice in their study that inherited only normal copies of the gene from their heterozygous parents did in fact have the white spots.

As reported in the new study, the researchers were able to postpone the onset of hearing loss and associated hair cell degeneration by about a month, providing enough time to inject normal copies of the Clarin - 1 gene into the ear before the onset of hearing loss to see if the treatment was effective.

The researchers knew that the cancer - causing mutations had arisen spontaneously in the women's ovaries because healthy cells taken from the same women contained normal copies of BRCA1.

If you're really excited about all this deliciousness then you can pre-order it now, there are signed copies available to order from Waterstones and normal copies from Amazon.

B (CARRIER / NOT AFFECTED): These dogs have one copy of the 52A > T mutation and one normal copy of DNA.

If you're a carrier of a defective gene for a recessive disorder, that means you have one normal copy of the gene from one of your parents and one defective copy from the other.

Both mouse and human males typically die early from the mutation in Mecp2, because their Y chromosome does not supply a normal copy of the gene.

The scientists are also experimenting with gene therapy, using a harmless virus to deliver a normal copy of the normal CIB2 gene to baby mice that have the mutated version.

The Penn scientists had engineered a weakened adenovirus, or cold virus, to deliver a normal copy of the OTC gene into the liver.

«You can't just put in a normal copy because that's not sufficient to change the disease,» says Allan Bradley, a geneticist at the Wellcome Trust Sanger Institute in Hinxton, UK, who is a co-author of the latest study.

The fusion technology possibly could be harnessed to provide muscle cells with a normal copy of the missing gene.»

The findings jibe with previous reports that PCR tests sometimes overlook a gene with large deletions, detecting only the other, normal copy of the gene.

Women tend to be protected from diseases related to genes on the X because female cells randomly inactivate one of the X chromosomes, and that leaves some cells with a normal copy up and running.

Like the girl, a few of them have two mutated copies, but most have one faulty and one normal copy.

In contrast, only 7 % to 15 % of newborns with mutated versions of either gene — or normal copies of both — were afflicted.

The finding also led them to the protein made by a normal copy of the gene that promotes sleep early in the night and properly regulates sleep cycles.

Researchers used a technique called CRISPR / Cas9 - mediated genome editing, which can precisely remove a mutation in DNA, allowing the body's DNA repair mechanisms to replace it with a normal copy of the gene.

Mice that inherit two normal copies of the gene should not exhibit this coloring.

The researchers bred together mice that each carried one normal copy of the gene and one aberrant copy — that is, they were heterozygous.

They frequently find that in both types of disease the region of the «healthy» copy of chromosome 17 that should carry the normal copy of the BRCA1 gene is missing, leaving only one copy of the gene — the one with the cancer - causing mutation.

Apparently as a result, the 13 people they studied end up heavier and packed with a significantly higher percentage of body fat than family members with two normal copies of the leptin gene, the team reports in the 1 November issue of Nature.

The virus was modified to make it harmless but nevertheless capable of introducing a normal copy of the FXN gene in the heart cells, thus leading to the expression of frataxin.

The childrens» parents weren't grossly obese, even though each carried one defective and one normal copy of the leptin gene.

Normal copies of the beta haemoglobin gene contain three coding regions of DNA interspersed with two non-coding sequences, known as exons.

Contrary to reports of premature deaths, carriers of the sickle - cell gene were in almost all cases healthy; because genes come in pairs, carriers had one normal copy of the gene, making normal hemoglobin.

If a mutated gene causes damage to or spurs the disappearance of a necessary protein, for example, gene therapy may be able to introduce a normal copy of the gene to restore the function of that protein.

But fish with a normal copy of the gene can't cope when researchers artificially block protein production from the same gene.

About 1 in 25 people in white populations carry one normal copy of the gene and one mutated copy, and 70 per cent of all CF carriers in the northern European group carry the same single mutation in the gene.

Because the girl inherited a defective version of the gene from each parent, she had no normal copy.

... When dopaminergic input comes in, [individuals with the SNPs on one gene copy] would have a chance of having more transmission» than those with two normal copies of the gene.

However, both parents also had a normal copy of IRF7, so they were healthy.

«Because individuals carrying a single mutant copy of a gene often mate with an individual with two normal copies of gene, defects can be hidden for a generation and then show up in the grandchildren,» Bier adds.

In a previous study, Shaw, an associate professor in Salk's Molecular and Cell Biology Laboratory and researcher in the Institute's new Helmsley Center for Genomic Medicine, demonstrated that cells lacking a normal copy of the LKB1 gene fail to activate AMPK in response to low energy levels.

In response, St. Jude researchers have re-engineered a lentivirus to function as a vector to ferry a normal copy of IL2RG into the patients» hematopoietic stem cells.

«People who have two «bad» copies of this gene have a frontal cortex that, by various biological measures, appears 12 years older than those who have two normal copies,» said Asa Abeliovich, professor of pathology and neurology in the Taub Institute for Alzheimer's Disease and the Aging Brain at CUMC and co-leader of the study.

«If a patient has a mutation in a specific gene, it would be a way of giving them a normal copy to try to correct that gene.

The researchers found that patients from MODY3 families had one of several different mutations in the gene for hepatocyte nuclear factor 1 alpha (HNF -1-alpha) but healthy subjects had normal copies of the gene.

The safety of interfering with the normal copy of the HD gene is important, considering the ongoing clinical trial of a huntingtin - lowering ASO.

What WAVE has done might get around these issues because their two drugs specifically target the mutant gene, leaving the normal copy alone.

In their analysis, the research team found that a process called compensatory uniparental disomy (UPD) was responsible for the complete replacement of the ring chromosome with a normal copy of chromosome 17.

To swap the defective gene with a normal copy in the iPSCs, the investigators used a modified adenovirus (common cold virus) that, unlike viruses used in other methods, does not replicate itself in the body and does not alter the host cells» DNA.

For the study, the researchers infused the boys» autologous hematopoietic stem cells with a lentivirus vector, Lenti - D, which delivered a normal copy of the ABCD1 gene when infused back into the bone marrow.