Participants with symptomatic heart failure and a left ventricular
ejection fraction of 45 percent or more (
normal or near
normal contractions) were randomized to receive either spironolactone (15 to 45 milligrams daily) or matching placebo, and were followed for an average of nearly 3.3 years.
Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular
ejection fraction (LVEF) ≥ 50 % of the lower limit of
normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criteria
Posted in coronary artery disease (CAD),
ejection fraction, heart disease, insurance, life insurance, LVEF Tagged cardiologist
normal is
normal, echocardiogram,
ejection fraction, insurance, life insurance, life insurance underwriter, lipid panel to die for, LVEF, medical test result
normal, medical test result not
normal enough, mistake that higher EF is better, no actuarial basis,
normal range 50 % to 65 %, treadmill stress test, underwriter low
normal is almost not
normal, underwriters playing doctor