Sentences with phrase «normal embryonic development»

Since the in vitro reprogramming systems are characterised by very low efficiency Petra's lab focuses on the systems where epigenetic reprogramming occurs naturally as a part of normal embryonic development.

It should be said that stem cell lines are quite different from normal embryonic development and these results should be interpreted with caution.

The role of FOXD1 in GBM, Nakano and colleagues say, suggests that the mesenchymal GSCs have hijacked the molecular mechanism of normal embryonic development to promote tumor growth.

EMT is crucial for normal embryonic development, but also operates in wound healing, and when abnormally switched on, can enable the spread of tumor cells.

Nanog appears in both the morula (12 - cell stage) and in high concentration at an advanced stage of normal embryonic development, the blastocyst (150 - cell stage).

Not exact matches

While the entity generated by deleting or disabling early embryonic genes would produce only an unorganized collection of stem cells, it would do so after a period of what appears to be relatively normal development.

The latest findings show that genetic defects in the body's ability to manufacture carnitine might be associated with an increased risk of autism because carnitine deficiency interferes with the normal processes by which neural stem cells promote and organize embryonic and fetal brain development.

The team suspects that the normal protein plays «a major role in embryonic development,» Auerbach says, perhaps in DNA repair and replication.

Their embryonic development is pretty normal — except for a bent great toe.

All of the mice produced normal amounts of SOX2 during development, when the transcription factor plays a critical role in the genesis of embryonic and neural stem cells.

If the egg were indelibly etched with asymmetric information that unequivocably determines development, the argument went, how could two embryonic cells be separated and still produce whole, intact, normal individuals?

But Mary Herbert, a reproductive biologist at the University of Newcastle, UK, who is part of a team pursuing mitochondrial replacement, says that mitochondria behave very differently in embryonic stem cells compared to normal human development.

Mutations in these animals began to amass during embryonic development, while normal animals don't begin to accumulate mutations until after birth.

My post-doctoral work on the identification of genes required for normal germ line development and fertility led to the discovery that the germ line is exquisitely sensitive to mutations in components of the mitotic spindle that have the potential to lead to aneuploidy — this sensitivity may also extend to embryonic and adult stem cells.

By the late 1800s, researchers understood cancer enough to realize that they must better understand normal development in order to better combat cancerous tumors and their embryonic - like cells (Brewer et al., 2009).

seek to identify the mutational processes underlying mutational signatures found in cancers, characterise the mutational processes operating in normal cells, use phylogenetic analyses of somatic mutations in humans to explore cellular lineages during embryonic development

They discovered that extra chromosome 21 - a genetic state known as trisomy 21 - disturbs a key regulating gene called NRSF or REST, which in turn disturbs the cascade of other genes that control normal development at the embryonic stem cell stage.

Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors.

During that time, she applied her knowledge of the processes governing normal heart development to direct the differentiation of embryonic stem cells into the cardiac lineage.

This current is a natural adjunct of embryonic development, present in all wild - type hair cells but declining after birth with emergence of the normal - polarity current.