Sentences with phrase «normal epithelial cells»

(23), and spheres were counted on day 5 to avoid counting of any mammospheres that may have arisen from normal epithelial cells.

Normal epithelial cells often exert anti-tumor effects against nearby oncogenic cells.

These findings uncover the mechanism by which normal epithelial cells recognize and eliminate oncogenic neighbors by cell competition.

The new research finds that the stiffness of the extracellular matrix and the availability of certain ligands (molecules that bind to cell membranes) can together determine which genes are actually called on — and whether normal epithelial cells begin to exhibit the behaviors characteristic of highly malignant cancer cells.

Not exact matches

In subsequent experiments, the Einstein team deciphered other parts of the Rac1 signaling cascade during invasion and showed that this signaling mechanism is regulated differently in normal breast epithelial cells.

genes, the team has shown that B. theta helps guide the normal development and functioning of the intestines — including the growth of blood vessels, the proper turnover of epithelial cells, and the marshaling of components of the immune system needed to keep less well behaved bacteria at bay.

Because mice lacking both genes would not be born alive, the scientists followed up this lead by making «conditional knockout mice,» in which Esrp1 and Esrp2 activity was normal early in fetal development, but then was switched off in skin epithelial cells.

The scientists now believe that the loss of normal function in the primary cilium leads to the uncontrollable division of renal epithelial cells, which contributes to the formation of ccRCC.

«We showed that PLK1 drives migration of normal prostate epithelial and prostate cancer cells through an entirely different process.»

When this model was in its softest mode, normal (benign) mammary epithelial cells behaved normally within it, forming cellular structures referred to as acini that capture many key features of the normal in vivo mammary epithelium.

By manipulating it in vitro, a team of researchers led by Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

The cell changes, known as an epithelial to mesenchymal transition, or EMT, are normal and helpful during wound healing, but problematic when cancer cells spread from the primary tumor site to other sites in the body.

«It is striking that these changes, found in many human cancers, can be induced in normal mammary epithelial cells simply by varying the stiffness or composition of the matrix surrounding them.»

These structures were further examined by tissue - level and immunohistochemical tools, revealing ducts with «excessive layers» of epithelial cells, potentially pre-cancerous lesions that were «highly proliferative» compared to normal ducts, they add.

They found that the protein seems to help maintain several traits in normal breast cells, including the ability to adhere to other epithelial cells, and the presence of molecules marking the cells as differentiated and not capable of self - renewal like breast stem cells.

Gut microbiota that live in the outer regions of the mucus and remain a safe distance from epithelial cells provide a benefit to the host, but Chassaing and Gewirtz hypothesize that microbiota that encroach upon host cells drive chronic inflammation that interferes with the normal action of insulin, promoting type 2 diabetes.

In the normal cells, PDX1 maintains the cells» identity as pancreas cells and epithelial cells.

The goal of the first experiment was to see whether lncRNAs are differentially expressed in prostate cancer by measuring total RNA from prostate cancer cell lines and normal epithelial prostatic cells using NCode human ncRNA array and SurePrint G3 human lncRNA microarrays.

We are examining the contributions of blood cells and epithelia to healing normal epithelial wounds.

When normal cells are transformed into cancer cells, this epithelial tissue can take on the characteristics of embryonic tissue, known as mesenchymal tissue, which is comprised of unspecialized cells that will develop, as the embryo matures, into more specialized tissues.

An instructive model of EMT is based on an experimental system employing normal primary human mammary epithelial cells (HMECs).

Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps at single nucleotide resolution in a low - passage breast cancer cell line and normal breast tissue (primary human mammary epithelial cells).

Furthermore, there was a negative expression for Cyclin D1 protein in normal ductal epithelial cells, while the benign group revealed week positivity immunostaining Cyclin D1 in 60 %, whereas, the malignant group represented a variable positivity of immunostaining scores; they were classified as 3 (10 %) cases were weak, 9 (30 %) moderate cases and 12 (40 %) strong expression cases.

Normal breast tissue showed acini lined by epithelial cells resting on an intact myoepithelial cell layer (Figure 1A).

As a normal comparator, they obtained primary epithelial mammary cells.

(A) Normal case: negative Cyclin D1 - immunostaining in the ductal epithelial cells, (B) Benign case: few nuclei with weak expression of Cyclin D1 of ductal epithelial cell, and negative one in stromal cells, (C) IDC GII case: a strong positive expression of Cyclin D1 in invasive ductal epithelial cells and stroma, (D) IDC GIII case: moderate positive expression of Cyclin D1 in trabeculae malignant cells, and absent in the vesiculated polymorphic nuclei.

In particular, they are focused on studying the functional role and molecular mechanisms of cellular senescence in both of these events, and how a deregulation of normal epithelial stem cell proliferation is involved.

Gene expression profiling of di - n - butyl phthalate in normal human mammary epithelial cells.

«Also in real life, organs have an epithelial lining, a vascular component, connective tissues and immune cells, none of which can yet be replicated in their normal physical arrangement in organoids,» says Donald Ingber, founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard University.

Uromodulin (or Tamm - Horsfall protein) is the most abundant protein in normal urine, specifically produced in the kidney by epithelial cells of the thick ascending limb (TAL) of Henle's loop.

For most of the cancer cells, 45 — 100 nM RIPK2 inhibitor 1 inhibited > 70 % of the proliferation of colon and blood cancer cells while preserving the proliferation of normal Rat - 1 and ModeK intestinal epithelial cells (Fig. 6A).

However, when challenged by an oncogene, the normal mammary epithelial cells in these involuted glands did not aberrantly activate STAT5 (Figure 8A) when compared to mammary cells that gained caErbB2 first and were later exposed to pregnancy hormones (Figure 3A).

In normal mammary tissues, LARP7 was highly expressed in the epithelial cells of the mammary lobuli and terminal ducts (Figure 1C).

Cambridge, Mass. — June 16, 2014 — A team of researchers led by David J. Mooney, Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences (SEAS), have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

Researchers discovered in this study that the growth of cancer cells is selectively halted with zinc but leaves normal esophageal epithelial cells untouched.

These flavonoids have almost no toxicity to human normal epithelial, peripheral and myeloid cells.

Lauric Acid inhibited the viability of both cancer cell types without altering the growth of MCF - 10A normal breast epithelial cells, thus suggesting its specific potential to trigger antiproliferative effects in malignant cells.