Sentences with phrase «normal gene function»

These alterations in non-coding DNA sequence can affect normal gene function, in addition to how much, when and where in the organism a melanocyte cell decides a gene product should be produced.

«Once we identify that disruption, we can begin exploring ways to restore normal gene function during early heart formation — and reduce the number of babies born with debilitating, and sometimes fatal, congenital heart defects.»

Targeted gene therapies, however, had to wait for (1) the identification of the genes to target, (2) the cloning and / or sequencing of the relevant genes and in some cases, the specific disease - causing variant, (3) a full understanding of the normal gene function and regulation, and (4) the development of efficient ways to deliver genes to the relevant tissues at therapeutic levels.

Not exact matches

Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.

Studies have shown that more than 50 % of all human cancers carry defects in the p53 gene, and almost all other cancers with a normal p53 function carry other defects which indirectly impair the cancer - fighting function of p53.

We all have ras genes, which make proteins that are vital to normal cellular function.

genes, the team has shown that B. theta helps guide the normal development and functioning of the intestines — including the growth of blood vessels, the proper turnover of epithelial cells, and the marshaling of components of the immune system needed to keep less well behaved bacteria at bay.

This question has been challenging to address experimentally because attempts to restore function to lost or mutated genes in cancer cells often trigger excess gene activity, causing other problems in normal cells.

Monsanto's newest drought - tolerant product, Drought Guard, relies on a gene that creates a chaperone protein to coat a plant's RNA during stressful conditions and maintain the plant's normal cell functions, while Syngenta's hybrid contains novel drought - tolerant gene combinations.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Cartilage formation (chondrogenesis) requires the normal function of Sox9, a protein that regulates the expression of chondrogenesis - related genes.

These genes are believed to be essential for the normal function of nerve cells, and previous studies have linked these mutations to problems with synaptic function — how neurons communicate with each other.

The best example of this occurs in what's called gene imprinting, where for example, females have two X chromosomes and one of those two X chromosomes must be inactivated in a cell in order for the cell's normal function.

To understand how DIXDC1 mutations put normal brain function at risk, Cheyette's team turned to mutant mice that lacked a functioning copy of the gene.

The specific mutations that the researchers observed are «dominant negative» mutations, meaning, when present on even one copy of P53, they are able to compromise the function of the normal protein, whose components are made from both gene copies.

Cereblon's normal function is unknown, but mutations in the gene encoding it are implicated in mild mental retardation.

The study supports the importance of the serotonin which is specified and maintained by a specific gene, the Pet - 1 gene — for normal functioning of the neurons, synapses and networks in the cortex, as well as proper development of brain circuitry.

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»

The alteration is predicted to result in the production of a shortened ETV6 protein that can not fulfill its normal function of binding to DNA and regulating the expression of other genes.

Several years later, Turek's team noticed that mice that lacked a functioning Clock gene were heavier than normal mice.

If a mutated gene causes damage to or spurs the disappearance of a necessary protein, for example, gene therapy may be able to introduce a normal copy of the gene to restore the function of that protein.

12 guide RNAs developed to find mutation «hotspots» along the dystrophin gene helped rescue cardiac function to near - normal levels in human heart muscle tissue.

«We hope that in the future, by fully understanding how this gene affects signaling in the brain, we may be able to identify drugs to restore the normal signaling balance in neurons and improve cognitive and social function in patients,» says lead author Dr. M. Chiara Manzini.

In April 2000, pediatric immunologist Alain Fischer at Necker Hospital in Paris announced that he and his team had successfully installed a gene that restores normal immune function in three baby boys with a rare genetic illness.

Knowing the origin of each cell and which genes control their normal function are the foundations for scientists to decipher the disease process and eventually to find out how to guide the cells to self - repair or even to build up a brand new organ using amended cells from the patients.»

Kicking the habit lets most genes return to normal function over time, but some are damaged forever.

A-T is caused by lost function in a gene, ATM, which normally repairs damaged DNA in the cells and preserves normal function.

Many of the insertion sites were located within genes that play key roles in normal brain function.

In the new study, the researchers said the converted motor neurons compared favorably to normal mouse motor neurons, in terms of the genes that are turned on and off and how they function.

An improved understanding of the biological background of musical aptitude can contribute new insights into, for instance, genes that affect normal brain functions, the interactions between genes and the environment and the significance of music as a form of therapy.

This shuttling mechanism is crucial to maintain normal function of our genes and prevent disease.

When the «healthy» HD gene functions as it should, one of its many jobs is in the development of normal embryos.

However, this cellular intervention alters the normal expression of hypophosphorylated retinoblastoma (RB) protein needed for the expression of genes involved in cell functions [3] and, therefore, results in an abnormal cell.

«The challenge is to pick these individual gene variations and to really drill down and try and understand their function both in the normal operation of the immune system and in the disease state.»

p53 is therefore well - studied as an oncogene, or a gene that when not functioning normally can contribute to a normal cell becoming cancerous.

The cystic fibrosis fix was elegantly simple: Deliver normal genes into the lung, and they would function in place of the faulty ones.

The next step based on these novel head and neck cancer discoveries, the scientists agree, is to tease out how the genes function in normal cells, whether they form the lining of the larynx, pharynx, or another anatomical site affected by head and neck cancer.

BDNF, a target gene of CREB, is reduced with age and in the AD brain [112] and is required for normal cognitive function [113].

We study learning and memory at the genetic level to understand the structure, regulation, evolution and biological function of genes that are required for normal learning and memory.

We use various approaches including genetics, genomics and cell biology to study gene functions in normal development and disease such as cancer.

The researchers not only had to figure out how SLC16A11 performed in normal circumstances, but also then determine how mutations in the gene disrupted that function.

This is where at the microscopic level the genes should function normal but something in the...

CRISPR has allowed scientists to tag and light up endogenous genes of interest to better understand normal protein function.

PABPN1â $ ™ s normal function appears to be making sure messenger RNAs from a variety of genes have a protective â $ œpoly Aâ $ tail that allows them to leave the nucleus.

It is dedicated to the development of KO / KI mice and their extensive and standardised analysis to understand the function of genes involved in immune response in normal and infectious conditions.

Cancer Center invesigators find that abnormal methylation disables tumor suppressor genes, leading to the loss of normal cell function.

Her current research is focused on discovering how normal and disease melanocyte cell states establish distinct regulatory DNA landscapes, and also determining how the combination of both genetic variation within these regulatory regions and environmental cell signals alter gene expression and normal cell function.

Several gene rearrangements have been engineered and their protein products have been expressed in both normal cells and cancer cells to understand the effects of each rearrangement on cell function and targeted drug effectiveness.

Every normal tissue or organ comprises multiple resident cell types that are heterogeneous with respect to their morphologies, functions, and gene and protein expression patterns.

We use the zebrafish model to identify genes and mechanisms that regulate normal heart development, function and regeneration, and that can contribute to cardiac diseases in humans.