Sentences with phrase «normal genes called»

Not exact matches

One blocks normal cycles by impeding the clock regulator genes called CLOCK: BMAL1.

Such plants have two mutant copies of a gene called hothead, which differ from the normal gene by a single base pair.

Several mutations were found in genes coding the machinery that makes mitochondrial proteins, and so would probably hinder mitochondria's ability to make the chemical fuel called ATP, which is used by normal cells.

He discovered a second clock gene, called timeless, that encodes another protein, TIM, which is required for a normal circadian rhythm.

Fragile X occurs when a segment in the FMR1 gene on the X chromosome called the CGG triplet repeat is lengthened from the normal 5 to 40 repeats to 200 repeats in people with full mutation FXS.

Mice without the leptin gene, called ob / ob, overeat, weigh in at three to four times normal, and develop symptoms similar to the obesity - related diabetes seen in humans.

Other researchers had linked the ank mutation to mouse chromosome 15; in this week's Science, Kingsley's team reports that it's a single typo in a previously unknown gene, which they called ank, that led to a protein about 10 % shorter than the normal version.

The two closely related regulatory genes are active in the normal development of mammals and govern how RNAs produced from the genes are joined to make final versions of the encoded protein, a process called alternative splicing.

Brains of fish missing the gene were relatively normal except there were cells missing from a region called the hypothalamus.

Researchers used a technique called CRISPR / Cas9 - mediated genome editing, which can precisely remove a mutation in DNA, allowing the body's DNA repair mechanisms to replace it with a normal copy of the gene.

The team reports that the adenomas grow from cells that express a gene called Lgr5 +, which is also active in normal intestinal stem cells.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

The best example of this occurs in what's called gene imprinting, where for example, females have two X chromosomes and one of those two X chromosomes must be inactivated in a cell in order for the cell's normal function.

They transplanted either normal or gene - corrected macrophages into the respiratory tracts of mice, which were bred to mimic the hereditary form of a human disease called hereditary pulmonary alveolar proteinosis (hPAP).

In normal development, all cells turn off genes they don't need, often by attaching a chemical methyl group to the DNA, a process called methylation.

It appears to do this by targeting little knots in their DNA, called quadruplexes, which are very different from normal DNA and which are especially found in faulty genes.

In 1993, Poirier and his Montreal - based team co-discovered an important genetic risk factor involved in the most common form of the disease: a defective gene, called Apolipoprotein E type 4 (ApoE4), that prevents the normal transport of cholesterol and phospholipids to the brain.

UBC Psychiatry Professor Dr. Weihong Song and Neurology Professor Yan - Jiang Wang at Third Military Medical University in Chongqing attached normal mice, which don't naturally develop Alzheimer's disease, to mice modified to carry a mutant human gene that produces high levels of a protein called amyloid - beta.

Now a study has found that the gene mutation's toxic effects require higher than normal levels of a protein called suPAR to trigger the onset and progression of the disease.

Comparing the damaged sites in normal cells before and after infection with H. pylori revealed that genes located close to the margins of the chromosomes, the so - called sub-telomeric regions, are more likely to be damaged after infection, as are genes that are active in gastric cells.

She and her colleagues found Karma, a mobile piece of DNA known as a transposon, inserted in the middle of an important gene for normal oil - palm fruit development called DEFICIENS.

They found that altering the activity of a gene called Cdk5 appeared to make the clocks run faster than normal, and the flies older than their chronological age.

The new research finds that the stiffness of the extracellular matrix and the availability of certain ligands (molecules that bind to cell membranes) can together determine which genes are actually called on — and whether normal epithelial cells begin to exhibit the behaviors characteristic of highly malignant cancer cells.

In oncology terms, this double - hit status is called «loss of heterozygosity,» or LOH, to signify that both versions (one from mom, one from dad) of the normal BRCA gene have been hobbled.

The researchers set out to understand how this drought tolerance came about by comparing the set of expressed genes (the transcriptome) in the mutants to that in normal (so - called wild - type) plants.

Too much p53 in bone - making cells called osteoblasts dials down a gene, H19, and a related protein, decorin, that would otherwise help stem cells mature (differentiate) to become normal osteoblasts.

A group of transcription factors collectively called the eye field transcription factors or EFTFs (pax6, rx1, tbx3 [or ET], nr2e1 [or tailless], six3, lhx2, and six6 [or optx2]-RRB- and the neural patterning gene otx2 are essential for normal eye formation [6].

A drug called Repoxygen delivers the EPO gene with some controls, so that when blood oxygen dips below normal, the body makes enough red blood cells to restore normal oxygen.

The study team injected patients with a vector, a genetically engineered adeno - associated virus, which carried a normal version of a gene called RPE65 that is mutated in one form of LCA.

They discovered that extra chromosome 21 - a genetic state known as trisomy 21 - disturbs a key regulating gene called NRSF or REST, which in turn disturbs the cascade of other genes that control normal development at the embryonic stem cell stage.

We are using a new technique, called single cell RNA sequencing, to isolate thousands of single neurons from human brain tissue, study all the genes that are expressed in each individual cell, and make cell - to - cell comparisons between normal, early stage and late stage AD.

In the study, functional Ikaros protein produced from the one remaining normal Ikaros gene was restored with a novel class of drugs that target a specific enzyme called casein kinase 2 or CK2.

They inserted mutated and normal human FABP7 genes into star - shaped glial cells called astrocytes.

One of them, miR - 142, is known to target a gene called APC that inhibits the renewal of normal stem cells.

«Low - Calorie Diet Slows Aging in Mice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdings.

Genes are inherited in pairs, and if a cat has two defective (mutated) genes (called a homozygous cat) this increases the risk of HCM further compared with a cat that has just one defective gene (and one normal gene, a heterozygous Genes are inherited in pairs, and if a cat has two defective (mutated) genes (called a homozygous cat) this increases the risk of HCM further compared with a cat that has just one defective gene (and one normal gene, a heterozygous genes (called a homozygous cat) this increases the risk of HCM further compared with a cat that has just one defective gene (and one normal gene, a heterozygous cat).

Since there are so many genes involved in polygenic traits such as HD, some few dogs with what we call a normal genotype (very few defective genes as evidenced by progeny results, for example) can be «forced» into dysplastic phenotypes if they are overfed and mineral - supplemented during their fast growth period.

American bulldogs that have one mutant and one normal gene are called carriers.

Corgi PRA is caused by a mutation in the gene called PDE6A whose normal state is essential for normal vision.

Called «genetically clear», «noncarriers» or, more formally, «homozygous normals,» such dogs pass the normal gene on to all their pups with a very high probability - which means that their pups have a very low risk of being affected with prcd.

Dogs that have one mutant and one normal gene are called carriers.