Interestingly, this influence appears to work both ways — a mild reduction in disease symptoms was seen when HD mice were treated with
normal glial cells.
Not exact matches
His lab differentiates iPSCs from autistic patients into neurons and
glial cells, which they suspect may be releasing cytokines at levels higher than
normal in autistic patients.
The protein comes from a culture of
glial cells, whose
normal job is to provide an environment in which nerve
cells can thrive.
«Within 3 weeks after expression of the NeuroD1 protein, we saw in the microscope that human
glial cells were reinventing themselves: they changed their shape from flat sheet - like
glial cells into
normal - looking neurons with axon and dendritic branches,» Chen said.
«More importantly, a retrovirus can infect only dividing
cells such as reactive
glial cells, but it does not affect neurons, which makes it ideal for therapeutic use with minimal side effect on
normal brain functions.»
The researchers compared mice with a
normal glymphatic system to those with a disabled gene that prevented
glial cells from assisting in the fluid flow.
ClC3 is a critical regulator of the
cell cycle in
normal and malignant
glial cells.
They inserted mutated and
normal human FABP7 genes into star - shaped
glial cells called astrocytes.