But when organoids grown from her gut were exposed to lumacaftor and ivacaftor, the organoids swelled like
normal gut tissue, a sign that the defective protein was working and that salt and water were flowing through.
Measuring a few millimetres across, the pieces of intestinal tissue made by the month - long process contain all the cells and features found in
normal gut tissue, and grow by the same route as in embryos.
Not exact matches
With the award - winning work, Sebastian Zeißig's group demonstrated that bacteria within the
normal gut microbiota can invade the intestinal
tissue and activate an enzyme in stem cells that facilitates stem cell growth and cancer development.
Authors conclude «restoration of
normal menses was caused by reduced inflammation in the ovarian
tissue and supports the hypothesis that the
gut immune system can influence autoimmune disease and inflammation.»
GUT supports the health of the gastric
tissues without negatively affecting gastric pH for
normal digestion.
Proposed causes for human IBD include defective immunoregulation of the
gut - associated lymphoid
tissue that may be precipitated by permeability defects, 14 infectious and parasitic agents, 15,16 and dietary allergies.13, 17 There is provocative evidence from clinical observations and animal models to incriminate
normal luminal bacteria or bacterial products in the initiation and perpetuation of canine IBD.18, 19 The clinical response to hypoallergenic or elimination diets suggest that dietary factors may influence the pathogenesis of canine IBD.8 - 11 The term «hypoallergenic» refers to a diet that is generally free of additives and preservatives, and contains a hydrolyzed protein source.