Not exact matches
Working with
human breast tissue, the new study's authors attempted to induce EMT in
normal cells; they figured they would just get fibroblasts, a type of connective tissue that is important in wound healing.
They compared
normal, non-cancer-forming
human breast tissue
cells with cancerous
breast cells using both of these treatments, contrasting them with
cells with unmanipulated mtDNA.
The researchers inserted between 10,000 and 40,000 of these small RNAs at once into
breast cancer, colon cancer, and
normal human cells in the lab.
This compound killed
human breast, prostate, lung, and liver cancer
cells, while sparing
normal cells.
Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps at single nucleotide resolution in a low - passage
breast cancer
cell line and
normal breast tissue (primary
human mammary epithelial
cells).
It has been reported that
human breast CSCs and
normal human mammary stem / progenitor
cells showed decreased expression of miR200c and other miR200 members and that restoring miR200c in
breast CSCs inhibits their ability to expand clonally and form tumors in vivo [38].