Sentences with phrase «normal human cell»

«It's one cell stretching out up to 1,000 times longer than a normal human cell,» said McDevitt.

Coleman added that further research is needed to determine whether cell fusion events between normal human cell types result in genomic catastrophe and neoplastic transformation.

This image shows normal human cells (left) and genetically modified cells developed by the Salk scientists to simulate Werner syndrome (right), which showed signs of aging, including their larger size.

The researchers found that CtBP can cause normal human cells to become cancerous when inserted into the cell's DNA.

The researchers inserted between 10,000 and 40,000 of these small RNAs at once into breast cancer, colon cancer, and normal human cells in the lab.

Viewed under a microscope, normal human cells can be seen to have 46 chromosomes, arranged in 22 pairs plus the two sex chromosomes.

Tumours develop from normal human cells through a complex process with multiple stages.

He observed that normal human cells had a finite lifespan in vitro and could execute only a limited number of cell divisions.

Not exact matches

But in the lab, when the scientists manipulated human cells to be able to create the water bear shielding protein — called Dsup — they showed about half the DNA damage as normal cells.

Perhaps because it is normal for human embryos to contain cells with the wrong number of chromosomes, which can cause them to self - destruct.

Working with human breast tissue, the new study's authors attempted to induce EMT in normal cells; they figured they would just get fibroblasts, a type of connective tissue that is important in wound healing.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.

Since pseudouridine modifications may affect various RNA molecules in different types of normal and malignant cells, «our discoveries pave the way for future avenues of research aimed at exploring the role of pseudouridine in human development disease,» concludes Cristian Bellodi.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

In this latest advance reported in PNAS, the Wyss team showed that the human gut - on - a-chip's unique ability to co-culture intestinal cells with living microbes from the normal gut microbiome for an extended period of time, up to two weeks, could allow breakthrough insights into how the microbial communities that flourish inside our GI tracts contribute to human health and disease.

For now, Porteus and his team found that their corrected human hematopoietic stem cells seemed to behave like normal, healthy human hematopoietic stem cells.

A decade ago, he replicated the entire human leukemia disease process by introducing oncogenes into normal human blood cells, transplanting them into xenografts (special immune - deficient mice that accept human grafts) and watching leukemia develop — a motherlode discovery that has guided leukemia research ever since.

The estimate is that normal, healthy adults have ten times as many microbial cells as human cells within their bodies; countless more populate the environment around us.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiply.

While testing the effect of many normal, non-cancerous, human cells on the sensitivity of cancer cells to chemotherapy, they found a specific sample of normal human skin cells that rendered pancreatic cancer cells resistant to gemcitabine.

In humans, a comparison of bone marrow from 14 normal bone marrow donors, 35 multiple myeloma patients and 11 patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher in the multiple myeloma cells.

A 2017 experiment, also in China, used CRISPR to edit DNA in normal, presumably viable fertilized eggs, or one - cell human embryos.

Although the Nppb - knockout mice lived a normal lifespan, when the researchers killed the receptor cells in the spinal cord, the mice died prematurely, suggesting that it could be dangerous to try humans, Hoon says.

A comparison of epidermal equivalents generated from iPSC, hESC and primary human keratinocytes (skin cells) from skin biopsies showed no significant difference in their structural or functional properties compared with the outermost layer of normal human skin.

In tests on human brain cells engineered to make more normal prions than usual, Hooper found that the cells secreted far less amyloid beta peptide than they would ordinarily.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Normal human colon cells, kidney cells, lung cancer cells and two strains of colon cancer cells didn't respond to the bacteria.

«Just one transplant of the human EPO - producing cells treated kidney anaemia in mice, keeping their haemoglobin levels in the normal range for the remaining 7 - month lifespan of the animals,» says Kenji Osafune, of Kyoto University in Japan, who led the team.

«We have converted skin cells to stem cells and developed a highly efficient process to convert these stem cells into kidney structures that resemble those found in a normal human kidney.

The vlincRNAs were shown to be present in cancerous cells as well as stem cells and normal human tissues.

In the lab, the antibiotics had no harmful effect on normal cells, and since they are already approved for use in humans, trials of new treatments should be simpler than with new drugs — saving time and money.

Antibodies to fusin blocked cell fusion and infection with normal CD4 - positive human target cells.

Subsequent transplant of millions of human T - ALL cells into normal mice that were then treated with an anti-CXCR4 drug induced remission within two weeks, with diseased spleen and bone marrow tissue nearly returning to normal.

Although electrolyte leakage is still undesired, its danger is minimized by the use of either the normal saline solution pumped into the body in most IV treatments or a cell - culture medium that contains amino acids, sugars, and vitamins in addition to sodium ions and thus mimics the fluid that surrounds human cells.

The study of these creatures has the potential to be rather robust in implications for regenerative medicine, an area of treatment for repairing or replacing human cells, tissues or organs on Earth to restore normal function.

The team's insights not only illuminate normal vertebrate development but also could lead to improved understanding of human spinal defects such as scoliosis, said Pourquié, who is also the Harvard Medical School Frank Burr Mallory Professor of Pathology at Brigham and Women's Hospital and a principal faculty member of the Harvard Stem Cell Institute.

Gottschling noticed that after about 25 cell divisions — the equivalent of middle age in humans — DNA errors in daughter cells started appearing 100 times faster than normal.

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

As controls, fibroblasts and secretions from normal lab rats, mice, and another rodent called the spiny mouse were powerless to stop the human cancer cells growing.

Interestingly, the outbreak strain grew at a normal pace in cultured human white blood cells, apparently by subverting the immune response to its benefit.

Most importantly, when the team disabled the HIF - 1α cellular alarm, BMP signaling in human FOP bone progenitor cells was restored to levels comparable to cells in normal oxygen.

Dr. Steinmetz and his team found the genome of the HeLa cell line that they sequenced differs dramatically from a normal human genome sequence.

«It is striking that these changes, found in many human cancers, can be induced in normal mammary epithelial cells simply by varying the stiffness or composition of the matrix surrounding them.»

Telomeres gradually break down and shrink as cells age, eventually leading to cell death which is a normal part of human growth and aging.

To overcome this hurdle, researchers genetically engineered human T cells to produce a CAR protein that recognizes a glycopeptide found on various cancer cells but not normal cells, and then demonstrated its effectiveness in mice with leukemia and pancreatic cancer.

To better understand the intestine in its normal and pathological states, researchers have created «organoids» by isolating intestinal stem cells from human biopsy samples.

When transplanted into rats with hypopituitarism — a disease linked to dwarfism and premature aging in humans — the lab - grown pituitary cells promoted normal hormone release.

Although this human Gut Chip recreated the villus epithelium of normal intestine and enabled new insights into how flow and cyclic peristalsis affects intestinal differentiation and function, it could not be used to study processes that relied on normal intestinal cells from individual donors, which, for example, is crucial for studying patient - specific responses for personalized medicine.

Experiments on mice and on heart cells obtained from infants born with congenital heart disease suggest that neuregulin 1, a human growth factor, can put infant heart cells on a path that mimics normal growth rather than stalling out.