Sentences with phrase «normal human cell types»
Coleman added that further research is needed to determine whether cell fusion events between normal human cell types result in genomic catastrophe and neoplastic transformation.
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Working with human breast tissue, the new study's authors attempted to induce EMT in normal cells; they figured they would just get fibroblasts, a type of connective tissue that is important in wound healing.
Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.
Since pseudouridine modifications may affect various RNA molecules in different types of normal and malignant cells, «our discoveries pave the way for future avenues of research aimed at exploring the role of pseudouridine in human development disease,» concludes Cristian Bellodi.
«This is the first report of a particular normal human precursor cell type that shows such telomere malfunction,» says Dr. Eaves.
The research highlights the importance of investigating different cell types in normal human tissues to understand the cellular origin of cancer and the factors that may contribute to its development.
Dr. Vijayanand also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.
The enzyme telomerase is present in more than 95 % of all types of human cancers and absent in normal cells in the body.
Vijay also oversees a large - scale effort to map epigenomic modifications in more than a dozen different types of human immune cells from normal individuals to understand how epigenetic variations cause susceptibility to disease.
(Type 2 is found more commonly in adult humans and cats, generally arises from obesity, and occurs when the cells of the body become resistant to normal amounts of insulin, as opposed to a lack of insulin production.)