Another important feature of this antibody is that it acts on a part of the virus that is not normally targeted by
the normal human immune response.
Not exact matches
The advance, reported in Proceedings of the National Academy of Sciences (PNAS) journal, for the first time allows scientists to analyze how
normal gut microbes and pathogenic bacteria contribute to
immune responses, and to investigate IBD mechanisms in a controlled model that recapitulates
human intestinal physiology.
With our
human gut - on - a-chip, we can not only culture the
normal gut microbiome for extended times, but we can also analyze contributions of pathogens,
immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological
responses of the intestinal tract.»
The authors said that this result suggests that the reason bacterial numbers are so high in these mice, and, by extension,
human LAD patients, is not because of a defect in the
immune system's surveillance mechanism but because of the inflammation caused by the
immune system's abnormal
response to
normal levels of bacteria in the gums.
Interestingly, the outbreak strain grew at a
normal pace in cultured
human white blood cells, apparently by subverting the
immune response to its benefit.