Sentences with phrase «normal human somatic cells»

Since the discovery that telomerase is repressed in most normal human somatic cells but strongly expressed in most human tumors, telomerase has become a target for therapeutic agents to combat human cancer.

The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity.

Not exact matches

seek to identify the mutational processes underlying mutational signatures found in cancers, characterise the mutational processes operating in normal cells, use phylogenetic analyses of somatic mutations in humans to explore cellular lineages during embryonic development