Sentences with phrase «normal human tissues»

Knowledge - based annotation aims to create a comprehensive overview of protein expression patterns in normal human tissues.

The research highlights the importance of investigating different cell types in normal human tissues to understand the cellular origin of cancer and the factors that may contribute to its development.

For instance, his team found that around 2000 genes are expressed at levels higher than those of normal human tissues because of the duplications.

The vlincRNAs were shown to be present in cancerous cells as well as stem cells and normal human tissues.

To streamline this process, Uhlén's team has created standardized arrays containing microscopic samples from 48 kinds of normal human tissue and 20 types of tumors.

Not exact matches

On a normal diet, the human body breaks down carbohydrates into glucose, which are used for energy or stored as glycogen in liver and muscle tissue.

Working with human breast tissue, the new study's authors attempted to induce EMT in normal cells; they figured they would just get fibroblasts, a type of connective tissue that is important in wound healing.

Human physiology is the science of the mechanical, physical, and biochemical functions of normal humans or human tissues or orHuman physiology is the science of the mechanical, physical, and biochemical functions of normal humans or human tissues or orhuman tissues or organs.

In contrast, transplant rejection happens because a normal healthy human immune system can distinguish foreign tissues and attempts to destroy them.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

While tissue engineering exists for restoring normal sexual function, such as lab - grown vaginas, this would take the practice into the arena of human enhancement.

In autoimmune diseases, so - called autoantibodies instead recognize normal components of the human body and contribute to tissue damage.

Changes in DNA methylation patterns compared with normal tissue have been associated with a large number of human malignancies.

Subsequent transplant of millions of human T - ALL cells into normal mice that were then treated with an anti-CXCR4 drug induced remission within two weeks, with diseased spleen and bone marrow tissue nearly returning to normal.

The study of these creatures has the potential to be rather robust in implications for regenerative medicine, an area of treatment for repairing or replacing human cells, tissues or organs on Earth to restore normal function.

They further utilized a new method developed in the lab to cultivate normal human stomach tissue.

«We can apply this method to any type of clinical sample and all types of human tissues, including normal and cancerous tissues,» said co-lead author Yongxin Zhao, PhD, of MIT's Media Lab.

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

12 guide RNAs developed to find mutation «hotspots» along the dystrophin gene helped rescue cardiac function to near - normal levels in human heart muscle tissue.

They compared normal, non-cancer-forming human breast tissue cells with cancerous breast cells using both of these treatments, contrasting them with cells with unmanipulated mtDNA.

In this collaborative study, Wilkinson and Yanjun Lu, PhD, at the Tongji University in China, and their research teams compared human lung IMT samples and normal lung tissue samples from the same patients.

The normal tissue atlas is the largest of the four sub-atlases and contains more than 13 million images of protein profiling in 46 human tissues of different origin.

Induced pluripotent stem cells that were reprogrammed from normal adult human tissue.

Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps at single nucleotide resolution in a low - passage breast cancer cell line and normal breast tissue (primary human mammary epithelial cells).

7/16/2008 Improved Culture System for Hepatitis C Virus Infection A University of California, San Diego School of Medicine researcher has developed the first tissue culture of normal, human liver cells that can model infection with the Hepatitis C virus (HCV) and provide a realistic environment to evaluate possible... More...

Upon orthotopic transplantation into immunodeficient mice, these organoids form normal pancreatic ducts and acinar tissue resembling fetal human pancreas without evidence of tumour formation or transformation.

Now, they have investigated gene expression in low - grade dysplastic lesions and normal stomach tissue from mice and in gastric cancer and normal stomach tissue from humans.

Rudensky's team compared Tregs in normal human breast tissues with those found in untreated breast tumors, and found that Tregs in tumors were capable of more potent and aggressive immunosuppressive action.

Building on this initial finding, the team examined brain tissue from AD patients and normal non-demented humans and found that collagen VI expression was also higher in the Alzheimer's disease patients.

We have developed a sequencing based approach to show similar in human tissues, finding around a third of cells in normal sun exposed facial skin carry cancer driver gene mutations.

Regenerative medicine is dedicated to the study of repairing, replacing or regenerating damaged human cells, tissues or organs to restore or establish normal function; and it has potential applications to treat a wide variety of conditions.

To the identify the tissue - wide expression pattern of this receptor, they screen the full human tissue atlas and find expression in a limited number of normal tissues and cancers, including some reproductive and lymphoid organs and cancers.

We are using a new technique, called single cell RNA sequencing, to isolate thousands of single neurons from human brain tissue, study all the genes that are expressed in each individual cell, and make cell - to - cell comparisons between normal, early stage and late stage AD.

Regenerative medicine aims to use adult or embryonic stem cells to replace or regenerate human cells, tissue, or organs and restore normal function.

The Human Protein Atlas contains images of histological sections from normal and cancer tissues obtained by immunohistochemistry.

The expression of the pituitary growth hormone - releasing hormone receptor and its splice variants in normal and neoplastic human tissues.

In a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissue.

Using human colon cancer cells and primary human fibroblasts isolated from tumors and adjacent normal tissues, Alexandros Glentis and colleagues at the Institut Curie addressed the question of whether the cancer cells or the CAF cells were responsible for the breakdown of the basement membrane that leads to cancer progression.

We have applied the knowledge gained in our studies of SCID mice to optimize them to serve as hosts for human normal and malignant cells and tissues.

We have collaborated nationally and internationally with colleagues to develop improved humanized mouse models and optimize the technologies used for engraftment of normal and malignant human cells and tissues.

Conclusions: In an analysis of peripheral blood mononuclear cells and intestinal tissues from patients with inflammatory bowel diseases vs controls, we found that reactivity to intestinal bacteria is a normal property of the human CD4 + T - cell repertoire, and does not necessarily indicate disrupted interactions between immune cells and the commensal microbiota.

The Barcode database provides gene expression information about thousands of mouse and human samples from different normal and cancerous cells / tissues obtained pre - or postnatally.

«GTEx will begin to provide researchers with a comprehensive view of genetic variation and a more precise understanding of how it affects genes critical to the normal function of tissues and organs,» said NIH Director Francis S. Collins, M.D., Ph.D. «This resource will add a new dimension to our understanding of human biology and the mechanisms that lead to disease.»

1) Phytonutrients: * Occur naturally in fruits and vegetables * Promote the function of the immune system * Help fight off viruses as well as reduce inflammation * Associated with the treatment and / or prevention of cancer and cardiovascular disease 2) Enzymes: * Responsible for metabolic processes that occur within a cell and are necessary for sustaining life * Assist and play a large role in digestion, energy production, blood coagulation and contraction of muscles 3) Amino Acids: * The basic building blocks of protein * Absorption of amino acids is essential for your metabolism 4) Essential Fatty Acids: * Reduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones and teeth

Regenerative medicine is the «process of replacing or regenerating human cells, tissues or organs to restore or establish normal function».

(B) The human body can not make the nutrients or can not make enough of them for normal tissue function.

Tamoxifen and flaxseed alter angiogenesis regulators in normal human breast tissue in vivo.

Proposed causes for human IBD include defective immunoregulation of the gut - associated lymphoid tissue that may be precipitated by permeability defects, 14 infectious and parasitic agents, 15,16 and dietary allergies.13, 17 There is provocative evidence from clinical observations and animal models to incriminate normal luminal bacteria or bacterial products in the initiation and perpetuation of canine IBD.18, 19 The clinical response to hypoallergenic or elimination diets suggest that dietary factors may influence the pathogenesis of canine IBD.8 - 11 The term «hypoallergenic» refers to a diet that is generally free of additives and preservatives, and contains a hydrolyzed protein source.

As in human medicine, multiple treatments are required to kill the cancer cells while minimizing damage to surrounding normal tissues.