Sentences with phrase «normal huntingtin»
Bates» team showed that a protein usually responsible for the editing of RNA message molecules actually sticks to expanded huntingtin RNA, but not to normal huntingtin RNA.
https://en.hdbuzz.net/
However, there is far less known about the role of normal huntingtin in adulthood.
In addition, he is also studying the normal huntingtin cellular function in autophagy and how expansion of the poly - Q repeat may impair this function in HD.
This led scientists to deduce that normal huntingtin is very important during development, especially in the brain.
We will need to continue to use caution when removing or lowering normal huntingtin in human studies
Importantly, both studies suggest that we need to continue our current cautious approach when lowering normal huntingtin in human studies.
Mutant huntingtin, although altered, is still present, and most people with HD have normal huntingtin, too.
With clinical trials underway, it's all the more important to understand the role of normal huntingtin in the adult brain.
The researchers introduced this extra gene, designed to be regulated in a way that is similar to normal huntingtin genes, by injecting rhesus macaque oocytes with a viral vector.
Not exact matches
Plus, there are other drugs being developed and tested that aim to slow or prevent HD in other ways, by helping restore normal functioning of the brain in the presence of the mutant huntingtin protein.
A better understanding of the normal role of the huntingtin protein would make developing treatments easier.
Because the helper complex makes translation more efficient, the result of this interaction was that the cells made more extra-length than normal - length huntingtin protein.
Some of these approaches to attack mutant huntingtin also reduce levels of the normal protein, including the Ionis huntingtin - lowering drug.
Another option may be the pursuit of «allele - specific» therapies, those that specifically target mutant huntingtin while leaving the normal form intact.
Current huntingtin - lowering drugs, called ASOs, are also given as individual doses separated by several weeks, with normal protein production expected to bounce back somewhat in between.
Because of the interaction with the helper complex, the cells made more extra-length than normal - length huntingtin protein.
15:19 - Nopoulos: KIDS - HD allows us to study not just HD but also the role of huntingtin in normal brain development
The more we understand about how the normal and extra-long huntingtin proteins are made and work in brain cells, the better equipped we'll be in the search for HD treatments.
Remember we're talking about normal, not mutant huntingtin here.
This interaction wasn't seen with normal - length huntingtin RNA.
As expected, they found that the normal and extra-long genetic instructions were both translated into huntingtin proteins when they met up with a ribosome (the chef from our analogy above).