Sentences with phrase «normal liver cells»

They suggest instead it could be an adaptive response within normal liver cells.

This doorway is located at the base of normal liver cells, hidden from the blood vessels.

This was found to cause lysis in hepatocellular carcinoma cell lines, but not in normal liver cells indicating that further experimental studies on SOCS3 could increase its future applicability as a cancer cell specific anti-cancer agent.59

Instead, it gets a payload of fish oil in the form of LDL - DHA nanoparticles that are selectively toxic to cancer cells without harming normal liver cells,» he said.

Ledley will transplant normal liver cells into a sick child with the aim of keeping the child alive until it is possible to find a donor for a conventional liver transplant, or to give the child's own liver function time to recover.

The scientists took the genes for the most effective liver cancer antigen receptors on those T cells, put those receptors on human T cells and the resulting engineered human T cells eradicated the cancer as well, without hurting normal liver cells, they report in the journal Hepatology.

«Nine months later, the cells had shown no signs of slowing down and were functioning like normal liver cells.»

The research team, led by Tony Reid, M.D., Ph.D., of the Moores Cancer Center at University of California, San Diego (UCSD), reports that in normal liver cells there is only one receptor — or doorway the vector uses to enter the cell.

To determine whether or not the damaging effects on cancer cells would affect normal cells — which are already programmed normally for apoptosis — they doused both cancerous liver cells and normal liver cells with CVE to examine the process of inducing apoptosis, which involves creating DNA damage as a precursor.

The researchers then demonstrated that normal liver cells could not be infected with an adenovirus, which led them to investigate where the receptor was located.

«In the process of proving that liver toxicity is not an issue in gene therapy, we have also shown that cancer cells metastatic to the liver are a perfect target for gene therapy because the cancer cells, but not the normal liver cells, are infected by the adenoviral vector,» said Reid.

A featured paper in the February issue of the research journal Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differences between cancerous and normal liver cells.

«At the same time, normal liver cells are protected.

This is because activation of the immune system in the presence of viral hepatitis may cause damage to normal liver cells.