In this collaborative study, Wilkinson and Yanjun Lu, PhD, at the Tongji University in China, and their research teams compared human lung IMT samples and
normal lung tissue samples from the same patients.
Researchers identified 1,661 differentially expressed gene features between tumors and airways compared with
normal lung tissue.
Not exact matches
They discovered that YAP1 is present at higher levels and interacts with OCT4 more in primary and metastatic
lung tumors than
normal tissue.
Expression of CXCL16 was higher in the colon and
lung tissue of GF mice than in
normal mice, and blocking that expression reduced the numbers of iNKT cells and the amount of inflammation in those
tissues.
In contrast to most
normal tissues, switching off autophagy by deleting ATG7 was dramatically destructive to established non-small-cell
lung cancers.
The samples included both
normal and cancerous
tissues of the breast,
lung, thyroid and ovary.
Their goal was to establish if systemic genetic inactivation of autophagy would have selective anti-tumor activity against Ras - driven
lung cancers while sparing most
normal tissues.
The characteristic scarring and loss of
lung vasculature was slowed in every mouse, and the
lung tissue of some mice began to return to
normal.
Various genetic testing methods were used to examine
lung tumors, uninvolved
lung tissue and
normal - appearing airways located varying distances from the tumors.
Previous research, including pioneering work at MD Anderson by this study's senior author Ignacio Wistuba, M.D., and others, has shown
normal - appearing
tissue close to
lung premalignant and cancer lesions may have tumor - associated molecular abnormalities.
Representative photomicrographs of
lung tissue from unvaccinated unchallenged mice (
normal) and from Balb / c mice two days after challenge with SARS - CoV that had previously been given PBS only (no vaccine) or live virus.
Work in the 1960s on the
lungs of guinea pigs led to a greater understanding of the function of chemicals that are released by
tissues when
normal biological processes are disturbedANCHOR.
Damaged pulmonary (
lung)
tissue loses
normal functional capacity, leading to hypoxia (oxygen deprivation).
They have the potential to cause pneumonitis, or inflammation of
lung tissue, which interferes with the dog's ability to have a
normal exchange of oxygen.
They can cause pneumonitis, inflammation of
lung tissue, that interferes with the dog's ability to breath and with the
normal exchange of oxygen.