Sentences with phrase «normal mice»

The phrase "normal mice" refers to mice that do not have any special or different characteristics or traits. They are just regular mice without any unusual or abnormal features. Full definition
By changing the times the lights went on and off during the night each week, the researchers modeled the effects of chronic jet lag in normal mice who were fed a healthy diet.
The brain activity confirmed their varying behavior: The brain cells of normal mice remained inactive when they were placed in the shock chamber, indicating the subjects recognized their surroundings.
These mice are different from normal mice in several key brain areas.
When these knockout mice were fed a high - fat diet, they gained as much weight as normal mice did, but they managed to remain sensitive to insulin.
At the same time, the rodents had an even greater response to social defeat stress than normal mice do, suggesting their brains also are more susceptible to a depressive - like state.
In the study, normal mice with a muscle injury received steroids just before injury and for two weeks after the injury.
While normal mice showed enhanced protein synthesis, the mice without the pathway did not.
Once researchers gave them bowls of very salty water, they, just like normal mice, would not drink it.
In subsequent tests, the mice with the mutation did a worse job than normal mice at learning new motor skills.
The mutant mice were also overall more active for longer periods — up to 20 hours compared to the typical 12 hours for normal mice.
The mutant mice also turned out to undergo a more surprising change: Unlike normal mice, they could eat a high - fat diet without gaining much weight.
And normal mice showed no ill effects from the drug.
Now, a Japanese team has figured out how to overcome nature's obstacles and has generated apparently normal mice by combining the genomes of two mouse eggs.
One major difference between normal mice and clock - disabled ones was the time at which the animals ate, the researchers observed.
Normal mice also stand up a lot to explore their cage.
The brain cells of normal mice seemed unaffected, suggesting the protein had stayed in the blood.
The scientists then set out to see whether they could use a drug to achieve the same effect in normal mice.
They could then compare fat tissue from those mice with tissue from normal mice.
When the team fed the mice high - fat diet, all grew obese, as did a group of normal mice.
The mice had no apparent physical abnormalities, and they performed learning and motor tasks just as well as normal mice.
The cells immediately began sticking to blood vessel walls, while normal mice were unaffected.
A third study showed that similar injections into normal mice caused some of the neurodegeneration typical of Parkinson's disease and the mice became less agile.
Styner found that when normal mice ran on a wheel as much as they wanted, their bone fat content substantially decreased.
The researchers measured 40 % more of the enzyme PDE4A5 in the brains of sleep - deprived mice than in normal mouse brains.
Mallat hopes to clarify the role of regulatory T cells with a new experiment: injecting the cells into genetically normal mice with atherosclerosis, to see whether the cells can treat the disease.
First, they gave the germ - free mice a transplant of bacteria from 4 - day - old or 16 - day - old normal mice, and then exposed them to a strain of Salmonella that can infect the gut but not spread body - wide.
When the researchers altered the animals» eating patterns by feeding normal mice only during the light cycle (a mouse's night), the numbers, types, and activity of the bacteria shifted as well.
Normal mice become insulin resistant during the day, when the nocturnal animals are mostly sleeping.
Normal mice produced more than four times more melanocytes than did the p53 «knockout» mice.
Levine's team wondered whether autophagy might be involved, so compared the effects of exercise on normal mice and mutant mice that could not increase autophagy.
Normal mice saw benefits, too: Muscles and pancreas cells healed better in...
Herein, we demonstrate that dietary deficiency in folate and vitamin E increased PS - 1 expression in juvenile and adult normal C57B1 / 6J and ApoE - / - mice and in aged normal mice.
When the scientists took normal mice and temporarily reduced cholesterol creation in the hypothalamus with a technique known as RNA interference, the animals started eating more and gained significant weight.
So did mice treated with breast milk that were genetically engineered to have guts lacking receptors to EGF, as well as normal mice treated with breast milk depleted of EGF.
When the scientists fed these mice a high - fat diet that clogged their arteries and performed a procedure similar to stent insertion, they found that the arteries in these animals were less clogged than in normal mice given the same procedure.
Since more Cx43 means less room in the bladder, the team speculates that although normal mice didn't stop producing urine when asleep, their bladders were able to hold more due to decreased Cx43 concentrations.
The researchers quickly demonstrated WWL113's effectiveness in two different mouse models of obesity - linked diabetes — one in which the mice are genetically programmed to become obese and diabetic, and another in which normal mice are made obese and diabetic with a high - fat diet.
Normal mice eat at night, while they're active; the clockless mice ate almost continuously.
This early hint that age - related changes in EP2 action in microglia might be promoting some of the neuropathological features implicated in Alzheimer's was borne out in subsequent experiments for which Andreasson's team used mice genetically predisposed to get the mouse equivalent of Alzheimer's, as well as otherwise normal mice into whose brains the scientists injected either A-beta or a control solution.
We have found that expression of C3 in normal mouse eyes leads to pathology similar to AMD in humans, including the creation of anaphylatoxins and the MAC.
Normal mice who received marrow from the Hoxb8 «knockouts» groomed themselves compulsively.
Mice genetically engineered not to produce a key cytokine (TNF - alpha) fared no better than normal mice during infections.
Normal mouse oocytes are known to form parthenotes in culture in response to chemical signals or temperature changes, but despite multiple attempts to implant them in a womb, none has ever survived to birth.
Repeated injections of cells into the immune - normal mice led to more rapid cell death, indicating that the immune system was becoming more efficient at recognizing and rejecting the cells.
Here, the AD model mice lacking PERK were able to successfully maneuver through the mazes at rates achieved by normal mice.
Compared with siblings that were fed normal mouse chow, mice given high - fat meals lost about 25 percent of their taste buds over eight weeks.
To test this hypothesis, the researchers gave ALR - deficient and normal mice alcohol for four weeks.
Researchers observed a 50 percent loss of cells when they injected normal mice with an agent that selectively kills dopamine neurons of the substantia nigra (to emulate Parkinson's) semiweekly for five weeks.
When the researchers examined mice with disrupted IL - 27 function, they found that they were more likely than normal mice likely to die when infected with the virus, and that they died as a consequence of rampant lung inflammation.
Frank M. LaFerla of the University of California at Irvine and his colleagues gave Alzheimer's mice and normal mice daily doses of the drug, known as AF267B, for eight weeks and then tested their ability to learn to locate a hidden platform in a tank of water.
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