Sentences with phrase «normal mice during»

Mice genetically engineered not to produce a key cytokine (TNF - alpha) fared no better than normal mice during infections.

Not exact matches

By contrast, these females retained a normal level of social interest in other females during estrus, and in male mice when not in estrus.

The main difference between these and normal mice is that there is no «quiet» wakefulness or napping during the normally sleep - enriched daytime period.»

In mice, activating this region using targeted chemical genetic techniques resulted in prolonged wakefulness during the animals» normal sleep periods.

During her postdoctoral work, Bissell noticed that removing mammary cells from a mouse and putting them into a culture dish caused them to lose not only their normal in vivo shapes, but also their ability to secrete milk.

All of the mice produced normal amounts of SOX2 during development, when the transcription factor plays a critical role in the genesis of embryonic and neural stem cells.

He noted mice studies where the nocturnal critters became obese if they ate during day and night but remained a normal weight if they only ate at night.

In normal mice, these neurons — a subset of nerve cells that release the neurotransmitter gamma - amino butyric acid (GABA), and so are called GABAergic neurons — are most active during waking periods when the mice are eating or grooming, two highly pleasurable activities.

In mice carrying the schizophrenia - associated mutation, early development was normal, suggesting that truncated Shank3 can adequately fill in for the normal version during this stage.

When the researchers altered the animals» eating patterns by feeding normal mice only during the light cycle (a mouse's night), the numbers, types, and activity of the bacteria shifted as well.

Sagawa and colleagues compared mice whose mothers had received 30 % fewer calories during pregnancy with normal controls and found that the underweight pups experienced a shift in timing: the normal increase in blood leptin a week earlier than usual.

Next, Abadir and colleagues compared the effects of different concentrations of losartan and valsartan on young diabetic and aged mice during the proliferation / remodeling phase of wound healing, which involves the regrowth of normal tissue.

During this period, the mice on the high - fat diet gained 30 to 50 percent more body mass than mice fed a normal diet, and they developed more intestinal tumors than mice on a normal diet.

Factors maintaining normal sperm tail structure during epididymal maturation studied in Gopc - / - mice.

«We were careful to have all of the mice eating a normal diet during the actual memory testing which suggests the effects of the ketogenic diet were lasting.

Glucose is the sole metabolic fuel used for nearly all brain functions under normal physiological conditions, but the brain will metabolize ketone bodies for energy when access to glucose is limited, as would occur during water - only therapeutic fasting in humans or during calorie restriction in mice.

«Low - Calorie Diet Slows Aging in Mice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdiMice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdimice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdings.

Moreover, it should be noted that ketogenic diets are only relatively high in protein18, 106 and that some recent studies have demonstrated that VLCKD can even cause a regression of diabetic nephropathy in mice.109 With regard to possible acidosis during VLCKD, as the concentration of KBs never rises above 8 mmol / l10 this risk is virtually inexistent in subjects with normal insulin function.

In addition, the normal diurnal feeding rhythms present in mice were significantly blunted in the mutant mice: on a standard laboratory 12 - h light: 12 - h dark (12:12 LD) cycle, nocturnal mice typically consume ~ 75 — 80 % of their total daily calories during the dark phase; in contrast, Clock mutant mice consume ~ 50 % (2).

Different mutations in HSF4 have been reported to cause both human autosomal dominant and recessive cataracts [97 — 99] and studies in mice have shown HSF4 is required for normal fibre cell differentiation during lens development [100, 101].