Sentences with phrase «normal mice given»

Not exact matches

Compared with siblings that were fed normal mouse chow, mice given high - fat meals lost about 25 percent of their taste buds over eight weeks.

Heijtz could even shift her germ - free mice towards «normal» behaviour and genetic activity by giving them a microbiome transplant, but this only worked early in their lives.

To test a nonpermanent approach, the team gave normal female mice the MIS protein as a twice - daily shot.

Normal mice, in contrast, exhibited no symptoms, even when given 10-fold higher doses of the substances.

For 8 weeks, they fed normal mice a high - fat diet and gave them daily injections of either TNP, a well - known IP6K1 inhibitor, or a placebo.

Once researchers gave them bowls of very salty water, they, just like normal mice, would not drink it.

When «depressed» mice and rats were given ketamine, the number of bursting cells was much lower, similar to the number in normal animals, Hu's team found.

Knowing that the SCN cells in their LHX1 - deficient mice were similarly impaired, a graduate student in Blackshaw's lab, Joseph Bedont, reasoned that their mice might now be able to return to normal temperature cycles if given pulses of heat.

For instance, they took just half the time of normal mice to venture into new avenues and well - lit spaces, yet gave up far sooner in a swimming endurance test.

Lastly, they plan to vary the timing of exposure to the various diets in the mouse model of autism, by, for example, giving pregnant mice a high - glycemic index diet and then keeping their pups on a normal diet.

The researchers found that Sp7 in normal mice was expressed only in the dental mesenchymal tissue that gives rise to odontoblasts; it was not expressed in the oral epithelium that gives rise to ameloblasts.

Given this finding, it was likely that mice without gp96 would develop signs of inflammatory bowel disease as they grew, unable to adapt to a normal diet.

Even the heterozygotes had communication problems: They emitted significantly fewer sounds over a given time period compared to normal mice.

In that time, the normal mice produced regularly, giving birth to a litter of seven or eight pups approximately every 21 days, for a total of about 60 baby mice.

The team compared the offspring of pregnant mice when given a low protein diet (8 per cent protein) and a normal diet (20 per cent protein).

Remarkably, giving animals injections of lithium salts — which mimics WNT signaling by inhibiting the molecule GSK3 — or giving animals a more specific GSK inhibitor, the researchers were able to restore normal synapse and spine numbers and also improve some of the most significant psychiatric - like behavioral abnormalities in these mice.

His team could return their α - CaMKII levels to normal by giving the mice a drug that blocked only the engineered copy.

The transgenic mice gave birth to fewer offspring than their normal relatives, which fits well with the evolutionary theory that there is a trade - off between longer life span and fertility.

To test the effect of the change, Tsien and colleagues at the East China Normal University in Shanghai gave mice a slight shock in a training chamber while playing a loud tone.

The mice infected with the space - grown germs had a mortality rate almost three times higher than that of mice given germs grown in normal gravity.

When given the option to hang out with another mouse or an object like an empty cup, the mutant mice spent just as much time with the object as with the other mouse, unlike normal mice, which prefer a living companion.

In this study, the researchers demonstrated that when normal mice were given kynurenine, they displayed depressive behaviour, while mice with increased levels of PGC - 1a1 in muscle were not affected.

For instance, they took just half the time of normal mice to venture into new avenues and lighted spaces, yet gave up far sooner in a swimming endurance test.

Moreover, normal mice, ordinarily killed or disabled by an ischemic stroke, were given a shot of a compound that blocks the action of IL - 21.

In baseline tests, the high - energy ankyrin - G mice usually swam longer, only floating for about 10 seconds of the 200 second test compared to the normal mice that floated about 50 seconds, but after several sessions with the bully mice, the ankyrin - G mice were quick to give up and float, remaining still for well over 100 seconds on average.

When the treated mice matured, the females gave birth to normal numbers of pups, another sign that the skeleton — specifically, the pelvis — had reached full adult size.

Yet when Evans and his colleagues recently gave a PPAR & # 948 - boosting drug to normal adult mice, the rodents developed no greater stamina than nondoped counterparts — until the researchers had the animals combine the drug with a workout routine.

The effectiveness of the drug also decreased when the normal mice were given antibiotics to wipe out their gut bacteria.

Since E. coli and Salmonella also affect adults, the researchers tested what happened when normal adult mice were given vancomycin, an antibiotic that selectively kills bacteria like Clostridia and Bacteroides.

Raised in a germ - free environment, and then given a transplant of gut microbes from a four - day - old normal mouse, these mouse were still able to resist Salmonella infection without any help from their immune system — but only when they had received a dose of added Clostridium first.

The resulting change in the appearance, behaviour or biochemical characteristics of the mouse then gives an indication of the gene's normal role in the mouse, and perhaps in humans.

Given this, I assume it would have to mean those max lifespan extending interventions you mentioned that work in normal mice (CR, Met Restriction, GH Knockout, IGF - 1 and Insulin Signalling Manipulation) reduce ALL major forms of fatal aging damage?

Representative photomicrographs of lung tissue from unvaccinated unchallenged mice (normal) and from Balb / c mice two days after challenge with SARS - CoV that had previously been given PBS only (no vaccine) or live virus.

Young said Celltex did a study in which it injected lab mice with 73 times the normal dose of 200 million cells that Celltex gives its clients, and none of the mice died, developed toxic organs or grew tumors.

Shown are sections from normal mice (no vaccine or live virus) and mice given PBS (no vaccine) or live SARS - CoV and then challenged with SARS - CoV.

Normal mice failed to discriminate yellow versus red lights when the light intensities were set to give equal activation of their middle wavelength receptor.

A study out of University of Chicago's Pritzker School of Medicine found that mice who were given daily 150 mg dosages of Panax Ginseng Berry Extract had significantly improved glucose tolerance and normal blood sugar levels after just 12 days!

Conversely, mice genetically engineered to produce less insulin had healthier fat cells, burned off more calories, and resisted weight gain, even when given a diet that makes normal mice fat.

The researchers found a similar, but smaller, difference in the mice that had been given normal food.