Sentences with phrase «normal mice showed»

And normal mice showed no ill effects from the drug.

Not exact matches

Reporting in The Journal of Neuroscience, they showed that neurons of the mouse forebrain depend heavily on NAD in normal cognitive function.

When normal and gene - altered mice got the high - fat diet along with varying levels of doxycycline, to induce GLP1 release, the normal mice grew fat and mice expressing GLP1 showed less weight gain.

In the ovary of a normal mouse (left), a large follicle is shown at a late stage of development (a light pink oocyte surrounded by follicular cells, inset).

But unlike the normal mice, those with altered macrophages showed no signs of inflammation, such as changes in insulin production, high levels of immune chemicals, and macrophages in their belly fat.

In contrast, control mouse pups dosed with plain saline solution showed normal connections throughout their cortical tissue.

They were also more sensitive to alcohol's effects than the normal mice were; studies have shown that the more sensitive a person is to alcohol, the less likely he or she is to abuse it.

Mineral deposits and bone formation around toe joints of mouse with mutation in the ank gene (mutant foot shown on right, normal skeleton on left).

In a study published October 30 in Neuron, the scientists show that mice genetically altered so they don't produce serotonin didn't scratch as much as normal mice when exposed to irritants.

A new study has determined that mice that spent time running on wheels not only developed twice the normal number of new neurons, but also showed an increased ability to distinguish new objects from familiar objects.

They then injected the protein into elderly mice with normal immune systems, and found this reproduced the beneficial effects of cord plasma on both memory performance and LTP in the hippocampus whereas mice engineered to lack TIMP2 showed reduced LTP.

In an article entitled «Prion protein modulates monoaminergic systems and depressive - like behavior in mice» and published in the Journal of Biological Chemistry, the group shows that mice lacking normal prions show a depressive - like behavior similar to depression symptoms found in patients with Alzheimer's and prion diseases, namely Creutzfeldt - Jakob Disease (CJD), variant Creutzfeldt - Jakob Disease (vCJD), Gerstmann - Sträussler - Scheinker syndrome, Fatal Familial Insomnia and kuru.

Post mortems showed that brain connections lost in the untreated mice remained healthy, and completely normal protein production had resumed in the treated animals, even though the prions continued to accumulate.

Normal mice watching chronically itchy mice in other cages increased their own scratching in as little as 5 seconds, whereas mice placed near nonitchy mice didn't show any increase in scratching, researchers report in Science.

Longo also knew of research by molecular biologist John Kopchick at Ohio University, which showed that mice with a mutation in their growth hormone receptor gene lived 40 percent longer than normal mice — the equivalent of an average American living to age 110.

Zeroing in on this kinase was encouraging, Goga said, because other researchers have shown that genetic - knockout mice that lack the entire family of PIM kinases are slightly smaller than normal mice, but «basically fine,» indicating that a drug targeting just PIM1 may have manageable levels of toxicity in breast cancer patients.

The octacosanol - administered mice also showed normal sleep, which was previously disturbed due to stress.

Experiments with mice show that after just four weeks on a high - fat or a high - sugar diet, the performance of mice on various tests of mental and physical function began to drop, compared to animals on a normal diet.

To show why, he pulls out a raft of study results collected in a large three - ring binder and points to several studies showing that mice subjected to stress developed more cancers than normal mice.

The hind paws of the normal mice became hypersensitive and blistered in response to the UVB exposure, while those of the mutant mice showed little sensitization and tissue injury.

Their study showed that mice without the Y6 gene were smaller, and had less lean tissue, than normal mice.

The quest for better opioids got a much - needed jolt in 1999, when researchers at Duke University showed that mice lacking a protein called beta - arrestin 2 got more pain relief from morphine than normal mice did.

The muscle fibers were larger and more numerous than in normal mice, and even after a year the mutant mice show no other abnormalities.

Abraham Kierszenbaum of the City University of New York Medical School has conducted experiments in mice showing that even normal - looking sperm from a mutant mouse «is likely to create infertile offspring.»

The genetically altered mice, however, had the same reaction when placed in the altered cages, while their normal compeers showed nary a trace of fear.

Other published data have already shown that FXR - deficient mice spontaneously develop steatohepatitis and liver tumors even when they are fed a normal rodent diet.

Bacterial counts from rodents» poop showed that although B. fragilis did not establish lasting colonies in the mice, they did «shake up the community,» of microorganisms, bringing it closer to that of the normal mice, Hsiao says.

A third study showed that similar injections into normal mice caused some of the neurodegeneration typical of Parkinson's disease and the mice became less agile.

That research showed that mice on a normal diet who were exposed to low doses of antibiotics throughout life, similar to what occurs in commercial livestock, packed on 10 to 15 percent more fat than untreated mice and had a markedly altered metabolism in their liver.

The researchers discovered that mice with genetic mutations that stop this endocannabinoid system from working properly age faster than normal mice, and show more cognitive decline.

«The J20 / caspase -2 null mice showed the same dendritic spine density and morphology as the normal mice — as opposed to the deficits in the J20 mice,» said co-lead author Julio Pozueta, PhD.

When bacteria from these «clockless» mice were transplanted into healthy animals living in normal light - dark conditions, the microbes began to show normal rhythms within a week.

But he adds that the study does not show that human astrocytes are genetically normal when engrafted into the mouse brain, and it does not rule out the idea that the improved learning and memory «could be due to the persisting progenitor cells.»

Those mice showed the expected signs of anxiety, such as moving around less open spaces and taking longer to start eating in new environments as compared with normal animals.

Compared with normal chow diet - fed mice, the high - fat diet mice showed worsened blood sugar, increased triglycerides, a type of fat (lipid) in the blood, and a substantial increase in the numbers of CD8 + T cells in the liver.

The researchers also showed that DENV NS1 caused similar levels of blood vessel leak in normal mice as in mice bred to have inhibited cytokine activity, suggesting that cytokines were not necessary for this effect.

Confocal microscope images show far fewer horizontal cells generated in mice without Onecut1 (bottom panels) compared to those in normal mice (top panels).

For example, Young's research shows normally monogamous prairie voles do not develop pair bonds with their mates if their mu - opioid system is blocked; other studies have found that mice genetically engineered to have no mu - opioid receptors do not prefer their mothers to other mice the way normal baby mice do.

As seen through a microscope, the leg bone of a normal mouse (left) makes considerably less new bone than a mouse that produces high levels of a signaling protein, WNT7B, that stimulates new bone growth (shown in pink on the right).

In two separate novel - object recognition tests, the CA2 - deficient mice showed a normal preference for an object they had not previously encountered, showing that the mice did not have a global lack of interest in novelty.

The study showed that mice lacking the SNRK gene had a significantly higher concentration of macrophages in white fat tissue compared with normal mice.

The green - labelled cells show a basal cell carcinoma in mouse tail epidermis derived from a single mutant stem cell and expanding out of the normal epidermis stained in red.

In contrast to studies that correlated elevated levels of IGF - 1 with the risk of developing prostate cancer, Greenberg's research showed that eliminating IGF - 1R expression in an otherwise normal mouse prostate caused the cells to proliferate and become hyperplastic.

Although the behavior of the mutant mice seemed mostly normal, further testing showed that they had deficiencies in spatial learning, confirming the enzyme's key role in that process.

Previous studies on DGKζ − / − and Cbl - b − / − transgenic mice have shown phenotypically normal thymic development but decreased presence of naive T cells (e.g., CD44loCD62Lhi) in peripheral immune organs (17).

Only a small number of these interventions — Calorie Restriction, Methionine Restriction, Growth Hormone Knockout, IGF - 1 and Insulin Signalling Manipulation — have actually been shown to extend maximum lifespan in normal, healthy mice.

Mice that had been eating a ketogenic diet performed at least as well on memory tests at old age as they did at middle age, while mice eating the normal diet showed an expected age - associated declMice that had been eating a ketogenic diet performed at least as well on memory tests at old age as they did at middle age, while mice eating the normal diet showed an expected age - associated declmice eating the normal diet showed an expected age - associated decline.

Shown are sections from normal mice (no vaccine or live virus) and mice given PBS (no vaccine) or live SARS - CoV and then challenged with SARS - CoV.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

In the current study, the mice showed normal slow gamma activity despite having fewer ripples.