We have found that expression of C3 in
normal mouse eyes leads to pathology similar to AMD in humans, including the creation of anaphylatoxins and the MAC.
Not exact matches
Top row,
eyes from
normal mice.
If one
eye is deprived of sight, they rapidly rewire their brains to compensate, then beat
normal one -
eyed mice on tests of visual acuity.
When the
eyes of her
mice looked
normal, Xu Wang was certain she had done something wrong.
In
normal mice with working photoreceptors (PR driven), stimulating the retina produces a variety of responses in retinal ganglion cells, the output of the
eye.
They found that the
mice can develop damage to the optic nerve despite
normal pressure in the
eye following KPro surgery and identified TNFa and IL - 1 as inflammatory factors involved in this process, with high levels of TNFa mediating the damage to the optic nerve.
Importantly, 25 of the 115 transcripts, shared by EFTF - expressing pluripotent cells and the EF, encode for 15 genes that are both expressed in retinal stem / progenitor cells and required for
normal eye formation in frogs, fish,
mice, or humans (Figure 1C; Table S1).