Neither
normal ovarian tissue nor benign ovarian tumors expressed HGMA2, they found.
Not exact matches
Sara Matthews, a consultant gynecologist at the Portland hospital, said that within three months of having her
ovarian tissue re-implanted, Al Matrooshi went from being menopausal to having the ovary function of a
normal woman in her 20s.
This resulted in the conception of a boy with
normal genitalia and a girl who was developing both
ovarian and testicular
tissue.
Spontaneous immune responses were assessed by measuring serum antibodies against
ovarian cancer - associated antigens, such as NY - ESO - 1, that are not expressed in
normal body
tissues but are expressed in cancers.
Normal tissue BRCA1 methylation is associated with risk for high - grade
ovarian cancer and may occur as a prenatal event.
Researchers from Haukeland University Hospital in Bergen, Norway, and colleagues analyzed for potential impact of
normal tissue BRCA1 methylation on
ovarian cancer risk.
For the new study, described in the October 23rd issue of Nature Communications, scientists at the Johns Hopkins Kimmel Cancer Center and Dana Farber Cancer Institute in Boston collected
tissue samples containing
normal cells,
ovarian cancers, metastases that had spread elsewhere, and small cancers found in the fallopian tubes, which included single cell layers of cancer called «p53 signatures» and serous tubal intraepithelial carcinoma, or STIC lesions.
The 5E5 antibody recognized multiple types of cancer cells, including leukemia,
ovarian, breast, and pancreatic cancer cells, but not
normal tissues.
Authors conclude «restoration of
normal menses was caused by reduced inflammation in the
ovarian tissue and supports the hypothesis that the gut immune system can influence autoimmune disease and inflammation.»