Not exact matches
The hope is that 3BP specifically kills certain cancer cells — while leaving
normal cells alone — because they rely more on glucose metabolism than on an alternative pathway called
oxidative phosphorylation.
Researchers focused on two pathways that produce energy in muscles, glycolysis (sugar metabolism) and mitochondrial
oxidative phosphorylation (OXPHOS) in both young and middle - aged rats that were fed a
normal diet or a calorie - restricted diet.
It was shown that chronically stimulated T cells proliferating in response to alloantigen in the context of GVHD greatly increased both glycolysis and mitochondrial
oxidative phosphorylation compared with
normal T cells (51).
This DNA becomes damaged in the course of
normal cellular processes, and certain forms of mitochondrial DNA damage - to the thirteen genes needed for
oxidative phosphorylation - produce malfunctioning mitochondria that can overtake their cells, either by replicating more readily or being more resistant to quality control mechanisms.
Iron is useful for participating in lots of different chemical reactions in the body, as part of
normal metabolism, but it's also important for caring oxygen to our tissues and oxygen is what we need in a process called
oxidative phosphorylation, which gives us energy.