Sentences with phrase «normal programmed cell»

The study found that curcumin is able to induce apoptosis (normal programmed cell death) in the most resistant breast cancer cells that lack estrogen receptors.

Often these mutations make the cancer cells resistant to normal programmed cell death, and the cells will divide over and over, forming a solid tumor.

Not exact matches

During normal development, epigenetic programming restricts both the genes a cell can use and the cell's developmental potency.

However, when the researchers knocked out SIRT1 in endothelial cells of 10 - month - old mice, then put them on a four - week treadmill running program, they found that the exercise did not produce the same gains seen in normal 10 - month - old mice on the same training plan.

One difference that is clear is that exhausted T cells express the programmed cell death protein - 1 (PD - 1), which commands them not to attack normal, healthy cells, but can also prevent them from striking at cancerous or chronically infected cells.

Multiple mutations in DNA — specifically, abnormalities in the p21 and p53 genes, among other changes — stop the process of apoptosis, or programmed cell death, that normal cells undergo.

«Under normal circumstances, myofibroblasts stimulate wound healing, but when there's an ongoing injury to an organ (e.g., the liver of a hepatitis C patient, the heart of a patient with high blood pressure, or the kidney of a patient with diabetes) these proteins clog up normal functioning,» said Humphreys, a Harvard Medical School associate professor at Brigham and Women's Hospital, who leads the Harvard Stem Cell Institute Kidney Program.

Along with restoring structure and function to the p53 mutant protein, this drug compound has the ability to to activate a program that selectively kills cancer cells with this particular mutation while leaving normal cells undisturbed.

Perhaps during normal inflorescence development, SMs poised to become bristles accumulate higher levels of BR, resulting in local increased cell division and expansion, loss of boundary identity genes, and repression of the SM identity program.

Paligenosis, Mills explains, appears similar to apoptosis — the programmed death of cells as a normal part of an organism's growth and development — in that it seems to happen the same way in every cell, regardless of its location in the body.

«Thanks to improvements in the understanding of AML biology, a multiplicity of so - called targeted therapies and therapies based on differential pathophysiology of leukemic stem cells compared with normal counterparts have emerged,» noted Richard M. Stone, MD, clinical director of the Adult Leukemia Program at Dana - Farber Cancer Institute in Boston, and colleagues, writing in a review for the ASCO 2017 Educational Book.

In particular, the scientists want to know more about how the vitamin influences the genetic programming of an embryo, which specific cells are impacted, and precisely how much retinoic acid is required for normal development.

In embryos where the mix of normal and abnormal cells was half and half, the researchers observed that the abnormal cells within the embryo were killed off by «apoptosis», or programmed - cell death, even when placental cells retained abnormalities.

These findings suggest that cancer cells subvert key genetic programs that guide immature cells to build organs during normal growth.

Our cells have built - in programming that sometimes veers them far away from their normal fate.

U.S. Military HIV Research Program (MHRP) researchers, however, have demonstrated that essentially all of the infectious virus particles can bind to the surface of red blood cells isolated from each of 30 normal (non-infected) human donors.

New data and research approaches have created opportunities for researchers to study in detail many aspects of cancer biology, including how the normal biological programs of cell proliferation and death are altered during cancer and how the immune system responds to tumors.

NCI supports and directs research on the biological differences between normal cells and cancer cells through a variety of programs and approaches.

Because programmed cell death goes awry in leukemias and other cancers, Hu is currently examining lincRNA - EPS's function in normal and diseased human cells in an effort to determine whether it plays a role in tumor development and growth.

In the breast, cancer stem cells and normal stem cells can arise from different cell types and tap into distinct yet related stem cell programs, according to Whitehead Institute researchers.

This program has provided the first comprehensive picture of how a gene normally associated with cancer can influence development, survival and normal function of brain cells central to age - associated neurodegenerative disorders such as Parkinson's disease.

Apoptosis is the programmed activity of a cell's self destruction or suicide, which is common with normal cells to make way for new replacement cells.

Anti-apoptotic proteins in cancer cells were inhibited, while normal cells» apoptotic programming was left intact.

To determine whether or not the damaging effects on cancer cells would affect normal cells — which are already programmed normally for apoptosis — they doused both cancerous liver cells and normal liver cells with CVE to examine the process of inducing apoptosis, which involves creating DNA damage as a precursor.

This is normal and to be expected when cells that have been programmed for decades to burn primarily glucose are now being deprived of this main fuel.

One of the functions of progesterone is to «turn on» the genetic programming that tells both normal and cancerous cells to die at the proper time.

It can also kill many different types of cancer cells by triggering apoptosis (programmed cell death) without affecting normal cells.

✓ Cytotoxicity — WGA has been demonstrated to be cytotoxic to both normal and cancerous cell lines, capable of inducing either cell cycle arrest or programmed cell death (apoptosis).

The virus activates growth - promoting genes in the DNA (oncogenes), at the same time it inactivates suppressor genes that would normally limit cell proliferation and alters the genes that regulate normal, programmed cell death.