Sentences with phrase «normal protein function»

Overexpression of fluorescently tagged proteins can lead to improper protein localization, protein aggregation, or disruption of normal protein function, and ultimately misinterpretation of the protein's cellular role.

CRISPR has allowed scientists to tag and light up endogenous genes of interest to better understand normal protein function.

Not exact matches

Vitamin B6 helps maintain healthy brain function, normal nerve function, forming red blood cells, and breaking down and digesting proteins.

An organic green blend, containing hemp protein, wheatgrass, barleygrass, pineapple, chlorella and spirulina powders Helps normal immune function, maintenance of normal skin and protection of cells from oxidative stress.

The observation that loss - of - function mutations in DENND5A causes epileptic encephalopathy suggests that DENND5A protein controls membrane trafficking pathways critical for normal neuronal development and strengthens the argument that protein trafficking processes in cells are critical for normal neuronal development and function.

But though myocilin is common in many parts of our bodies, its normal, healthy role in the eye and, for that matter, what functions the protein has in the body at all are still a mystery.

Changes in the normal function of Ras proteins — mutations which are responsible for 30 percent of all cancers — can power cancer cells to grow and spread.

Allan Jacobson, Ph.D., of the University of Massachusetts Medical School and co-founder of PTC Therapeutics, the company that developed ataluren, and David Bedwell, Ph.D., professor of the UAB Department of Biochemistry and Molecular Genetics, have sought to understand precisely how ataluren allows the ribosome, the machinery of cellular protein synthesis, to skip over these inserted stop signs and produce proteins that have normal or near - normal function.

Or does the drug allow insertion of dissimilar amino acids that may distort the structure of a read - through protein, preventing it from normal function?

Payne keyed in the symptoms, and the computer program suggested a handful of potential conditions, including a rare disease called amyloidosis, in which abnormal proteins build up in the body, interfering with normal organ function and causing nerve damage.

Calcium, however, puts a strain on cells — it is known to hinder protein - folding and metabolism when it accumulates — disrupting normal cellular function.

Restoring normal function to a mutated protein is more difficult than simply blocking a protein, the strategy used by most medical therapies, says Klas Wiman, a tumor cell biologist at the Karolinska Institute in Stockholm.

We all have ras genes, which make proteins that are vital to normal cellular function.

The UPR is triggered when the normal functions of the endoplasmic reticulum — the cell's largest organelle in charge of making and folding proteins — are compromised.

Monsanto's newest drought - tolerant product, Drought Guard, relies on a gene that creates a chaperone protein to coat a plant's RNA during stressful conditions and maintain the plant's normal cell functions, while Syngenta's hybrid contains novel drought - tolerant gene combinations.

Cartilage formation (chondrogenesis) requires the normal function of Sox9, a protein that regulates the expression of chondrogenesis - related genes.

In normal cell function messenger chemicals, such as various growth factors and insulin, bind to protein receptors on the cell's surface.

«Too little of this protein disrupts normal stem cell function, but too much can promote abnormal growth and lead to cancer.

Detecting protein - protein interactions is key to understanding both normal and abnormal functions in the cell.

Proteins control essentially all biological processes in a cell, and while they may sometimes act alone, proteins most often interact with other proteins to carry out their normal biological fuProteins control essentially all biological processes in a cell, and while they may sometimes act alone, proteins most often interact with other proteins to carry out their normal biological fuproteins most often interact with other proteins to carry out their normal biological fuproteins to carry out their normal biological functions.

The data indicate that CHD1's normal function is the loosening of DNA around break sites in order to facilitate the access of HR repair proteins.

Not only did the normal mice develop plaques, but also a pathology similar to «tangles» — twisted protein strands that form inside brain cells, disrupting their function and eventually killing them from the inside - out.

All the ApoE proteins have the same normal function: carrying fats, cholesterols and vitamins throughout the body, including into the brain.

This focus on the host side also comes with a potential drawback, the possibility that a drug might compromise the normal function of the protein.

The specific mutations that the researchers observed are «dominant negative» mutations, meaning, when present on even one copy of P53, they are able to compromise the function of the normal protein, whose components are made from both gene copies.

But mutations, which are found in 96 percent of patients with high - grade serous ovarian tumors, can cause p53 to form clumps, or «aggregates,» which impair the protein's normal function.

«Our study sounds a serious warning about the possible detrimental side effects of this strategy, since we have shown that such antibodies cause dramatic degeneration of nerve cells by interfering with the normal on - off function of the prion protein,» he added.

Under ordinary circumstances, the protein tau contributes to the normal, healthy functioning of brain neurons.

The alteration is predicted to result in the production of a shortened ETV6 protein that can not fulfill its normal function of binding to DNA and regulating the expression of other genes.

If a mutated gene causes damage to or spurs the disappearance of a necessary protein, for example, gene therapy may be able to introduce a normal copy of the gene to restore the function of that protein.

«Any protein that interacts with PrP is likely to be interesting,» says cell biologist David Harris of Washington University in St. Louis, because it may be involved in both the protein's normal function as well as the disease - causing conversion.

These stem - cell generated prostates secreted the same proteins as normal, functioning prostates.

They found that aggregated proteins were disentangled and resumed their original functions without exception after cells returned to normal temperatures.

«ECPR and a factor in the blood called protein C act as a «brake» on blood coagulation and endothelial cell inflammation and also enhance the viability and integrity of blood vessels, but when the malaria parasites use PfEMP1 to bind EPCR, they may interfere with the normal function of EPCR, and thus the binding can be the catalyst for the violent reaction,» he explains.

The team found that a specific mutant lacking the ferredoxin - 5 protein was unable to grow in the dark (in the nighttime) or perform normal metabolic functions, but it had no trouble growing during the light (in the daytime).

Most drugs exert their therapeutic effect by binding to a target protein molecule, thereby interfering with the normal function of the protein.

Today, a team led by dos Santos, in collaboration with Professor Gregory Hannon of Cancer Research UK, Cambridge Institute, and Assistant Professor William Pomerantz at the University of Minnesota, identify a protein that they show must be present in order for mammary stem cells to perform their normal functions.

This increases production of the protective protein Annexin - A1, reduces production of inflammatory cytokines and restores normal cell function.

«Under normal circumstances, myofibroblasts stimulate wound healing, but when there's an ongoing injury to an organ (e.g., the liver of a hepatitis C patient, the heart of a patient with high blood pressure, or the kidney of a patient with diabetes) these proteins clog up normal functioning,» said Humphreys, a Harvard Medical School associate professor at Brigham and Women's Hospital, who leads the Harvard Stem Cell Institute Kidney Program.

Along with restoring structure and function to the p53 mutant protein, this drug compound has the ability to to activate a program that selectively kills cancer cells with this particular mutation while leaving normal cells undisturbed.

The tag in their unique method is made up of a «tetracysteine motif» — two pairs of the amino acid cysteine separated by two other amino acids that doesn't interfere with the normal function of the protein of interest.

However, this cellular intervention alters the normal expression of hypophosphorylated retinoblastoma (RB) protein needed for the expression of genes involved in cell functions [3] and, therefore, results in an abnormal cell.

Finally, we generate new tools and mouse models to study the role of de novo protein synthesis in normal brain function and in pathophysiology associated with neurodevelopmental and neurodegenerative disease.

Our bodies need to do this to maintain homeostasis or normal functioning by breaking down proteins and turnover of the destroyed cell organelles for new cell formation.

When aSyn was produced at low levels, it made its way to the cell membrane and appeared to regulate chemical trafficking and metabolism of compounds called lipids — what may be normal functions for this protein.

When the function of some proteins involved in chromatin - remodeling was changed, normal ESC proliferation and differentiation was also affected.

«It may be that the normal TEL allele successfully suppresses the function of the aberrant TEL - AML1 protein resulting from the fusion, so full - blown leukemia doesn't occur,» said the lead author of the study, Joseph Wiemels, PhD, now a UCSF assistant research molecular epidemiologist.

Finally, the researchers observed that several proteins that are important for healthy brain function returned to normal levels.

Scientists have glimpsed the three - dimensional structure of a protein that protects the ends of human chromosomes, a function that is essential for normal cell division and survival.

The normal role of Ro was not well understood although it was known that the protein is normally found bound to small RNA molecules called Y RNAs, whose function remains somewhat mysterious.