Sentences with phrase «normal sequence of»

It is but the normal sequence of alternating climate changes that has been going on for thousands of years.

First, the government decided to write a draft strategy before requesting support from the World Bank - managed REDD + fund: the Forest Carbon Partnership Facility (FCPF), thus reversing the normal sequence of events.

It's actually a very speedrun - friendly game, even if you play it straight and don't try to break the normal sequence of the game.

(g) Language development and communication skills to include normal sequence of expressive and receptive language development and identification of communication deficits and appropriate interventions;

With these sites blocked, the splicing machinery focuses on the original — and correct — splice sites to produce the normal sequence of mRNA.

In some families, the patient who was tested had normal sequences of BRCA1 and BRCA2, but her relatives with breast cancer carried a mutation in one of those genes.

Not exact matches

On this basis, Eigen maintains that abrupt changes of a quite major sort are to be expected in the normal course of events, as a quasi-species centered on one sequence is rapidly replaced by a rather different successor quasi-species centered quite far away on one of the extensions of the former species.

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The nucleotide in M1 RNA, residue C92, which participates in a crosslink with the substrate was deleted and the resulting mutant M1 RNA was shown to cleave substrates lacking the 3» terminal CCAUCA sequence at sites several nucleotides away from the normal site of cleavage.

Using RNA sequencing, the researchers found multiple genes whose abnormal expression could lead to the high rate of death for cloned embryos, including failure to implant in the uterus and failure to develop a normal placenta.

The second part of the system can cut mutations out of the genetic code, and in some cases can replace the mutation with a normal genetic sequence.

By comparing the genetic sequences of the mutant and normal flies, the researchers found that the forgetful flies had an inactive copy of a gene that he and his Chilean collaborators dubbed Volado (Vol)-- South American slang for absentminded.

Since its launch in 2010, the project has sequenced the complete normal and cancer genomes of 700 young cancer patients with some of the most aggressive and least understood cancers.

They also ruled out other possibilities, including the gene spontaneously mutating back to the normal form, the existence of more than two copies of the hothead gene, or closely related DNA sequences providing a template for repairs.

The extra bone that appears in FOP flare - ups progresses through a cartilage stage before replacement with mature bone cells, following a sequence of bone formation seen during normal skeletal development.

To illuminate the process, the Yale team sequenced normal, primary, and metastatic tumor tissue from multiple individuals, including subjects with a range of cancer types.

To prove that the UL6 protein sequence does in fact trigger the autoimmune attack of HSK, Cantor and his team have now infected mice with either normal HSV - 1 or a strain that they had genetically altered to lack the UL6 protein.

In the first study of human fungal skin diversity, National Institutes of Health researchers sequenced the DNA of fungi at skin sites of healthy adults to define the normal populations across the skin and to provide a framework for investigating fungal skin conditions.

«What's critical with this and what has never been done before is that a single peptide sequence will work against the toxic versions of a number of different amyloid proteins and peptides, regardless of their amino acid sequence or the normal 3 - D structures.»

«Humans vary in their DNA sequences, and what is taken as the «normal» DNA sequence for reference can not account for all these differences,» says Stuart Orkin, MD, of Dana - Farber Boston Children's Cancer and Blood Disorders Center and co-corresponding author on the study with Matthew Canver, an MD - PhD student at Harvard Medical School.

While normal HD genes include up to 40 copies of the DNA sequence CAG, the mutated version is crammed with many more copies.

Gore and her colleagues believe these effects are epigenetic; that is, rather than inducing genetic mutations, which would change the sequence of the rats» DNA, the fungicide is permanently silencing or reprogramming normal genes that control development and behavior.

M1 RNA, the catalytic RNA subunit of Escherichia coli ribonuclease P, can cleave novel transfer RNA (tRNA) precursors that lack specific domains of the normal tRNA sequence.

Aggressively injecting a sperm into an egg manually has been found to change a whole sequence of molecular events in fertilization; for example, the dna packaged in the head of the sperm unravels more slowly than in normal fertilization, throwing off the timing of the process.

Dr. Steinmetz and his team found the genome of the HeLa cell line that they sequenced differs dramatically from a normal human genome sequence.

This study uncovered non-coding RNAs» cancerous role by using high - throughput sequencing techniques to analyse reams of genetic information on normal and diseased tissue as part of the Cancer Genome Atlas project.

DNA sequencing of sperm from the grandfather mice and their pups also revealed epigenetic marks on the gene encoding M71 that weren't seen in normal mice.

The researchers found that over 25 percent of index patients with normal results from commercial testing of BRCA1 and BRCA2, but with families severely affected by breast cancer, could be resolved by sequencing all genes known to be involved in breast cancer.

Without this approach, the results of genomic sequencing would have been swamped with DNA from normal cells, making it difficult to detect cancer - linked DNA errors, Papp says.

The vast majority of those patients were told that their gene sequences were normal.

They conducted complete genomic sequencing of all genes implicated in breast cancer on DNA samples from breast cancer patients who had normal BRCA1 and BRCA2 commercial test results.

Cloning and sequencing of complementary DNA's from normal and WHHL rabbits, shows that this defect arises from an in - frame deletion of 12 nucleotides that eliminates four amino acids from the cysteine - rich ligand binding domain of the LDL receptor.

In this proof - of - principle study, the researchers showed, using DNA sequencing and karyotyping technologies, that the patient's unique cell characteristics were maintained in both normal and tumor CR laboratory cells.

They also tested to see if the drug was inhibiting production of normal RNAs in the cells, and found that it altered less than 5 percent of normal RNA sequences

The convergence of several factors explains the trend: cheaper genetic sequencing technologies, the discovery of new oncogenes (genes that can cause a normal cell to become cancerous), a new generation of computers and bioinformatics that can analyze vast amounts of data, and a multibillion - dollar effort by researchers inside and outside the pharma industry to develop targeted drugs and companion diagnostics for cancer.

Tom Bebee PhD, a postdoc in the Carstens lab and Rohacek compared RNA sequences from the cochleae of normal versus Esrp1 knockout mice.

Future additions to the RM collection may include whole genomes from persons with Hispanic, African and mixed ancestries, as well as a set containing sequenced genes of both malignant tumor and normal cells from the same individual.

By focusing on several of these mutations and screening through guide RNA variants with different mismatch combinations, they were able to identify specific guide RNAs that stimulated Cas9 activity towards the mutated gene sequences but left the normal counterpart untouched.

«We hypothesized that for a given pair of targets that differ by a single point mutation, a set of mismatches could be identified in the guide RNA that would eliminate Cas9's activity on the normal sequence while maintaining robust activity on the one with a deleterious point mutation.

Although the researchers only sequenced about 2 % of the mother's and fetus's genome, this was enough data to distinguish levels of chromosome 21 in mothers carrying a Down syndrome baby from those with a normal fetus as early as 14 weeks.

Searfoss estimates that only about 5 percent of a commander's launch training is running through normal sequences — the rest of the time is spent learning how to cope with emergencies.

But by sequencing the entire genomes of seven prostate tumors and comparing them with genomes from the patients» normal cells, the researchers discovered an unexpected phenomenon.

Disruption of this structure caused DNA synthesis to proceed beyond the normal template boundary, resulting in altered telomere sequences, telomere shortening, and cellular growth defects.

Targeted gene therapies, however, had to wait for (1) the identification of the genes to target, (2) the cloning and / or sequencing of the relevant genes and in some cases, the specific disease - causing variant, (3) a full understanding of the normal gene function and regulation, and (4) the development of efficient ways to deliver genes to the relevant tissues at therapeutic levels.

First of all, only the metastatic sample was whole - genome sequenced — the primary tumor and matched normal were not.

We developed SomaticSniper to detect somatic mutations in whole - genome sequencing data while allowing for tumor contamination of normal cells that occurs in some types of leukemia.

By conducting an RNA - sequencing experiment of 103 matched tumour and normal colon mucosa samples from Danish CRC patients, 90 of which were germline - genotyped, researchers from the collaborative European project SYSCOL show that both inherited and acquired mutations in non-coding regions of the genome also contribute to cancer development and progression (Linda Koch, Nature Reviews Genetics).

Another collaboration was unfolding among the cancer geneticists, sequencing experts, clinical researchers, and surgical oncologists at Johns Hopkins, MD Anderson, and Baylor College of Medicine to study 32 pairs of head and neck tumor and normal tissue samples by whole - exome sequencing and validate the findings in an additional 88 samples.

Just as one can't truly identify somatic mutations in a tumor tissue without a matched normal, it's nearly impossible to distinguish de novo mutations in a patient without sequencing both of his or her parents.

Grandis and Garraway decided to study a University of Pittsburgh collection of 74 pairs of tumor and normal tissue samples using the Broad's capacity to perform whole - exome sequencing.