The immune system treats
normal skin cells as pathogens and tries to grow new ones, causing overgrowth of skin cells.
Using melanoma cells and both young and
old normal skin cells as a model, the lab is trying to unravel what these changes may be, and how they affect tumor progression.
Like Medieval alchemists who searched for an elixir that could turn base metals into gold, biology's modern alchemists have learned how to use oocytes to
turn normal skin cells into valuable stem cells, and even whole animals.
Thomson and Yamanaka had published independent studies the previous fall saying they could turn
normal skin cells into inducible pluripotent stem cells (ones that are most therapeutically useful because they can become any of the 200 different types of cells in the body); Bush was saying that this new type of stem cell would give us all the biological usefulness of the embryonic variety with none of the nasty ethical hang - ups.
Psoriasis occurs when there is excess production of skin cells after the immune system mistakes
normal skin cells for pathogens.
«Using healthy skin to identify cancer's origins: Cancer - linked DNA changes in 25 per cent
of normal skin cells.»
To determine whether L1CAM has a role in cancer, the researchers looked for its protein
in normal skin cells, cultured noncancerous cells, and aggressive melanomas from 11 patients.
In collaboration with Pr Véronique Del Marmol (Department of Dermatology, Erasme Hospital, ULB) and the group of Pr François Fuks (Laboratory of cancer epigenetics, Faculty of Medicine, ULB), Larsimont and colleagues demonstrated that while Sox9 is not expressed in
the normal skin cells, Sox9 begins to be expressed in pre-cancerous lesions and is maintained in invasive tumors.