I'm not prepared to endorse such a high B6 / B12 dose — 100 mg B6 and 5 mg B12 are more normal therapeutic doses — but will look into the paper you cited when I have time.
TIC10 seems to be nontoxic to normal cells or mice even at doses 10 times higher that an observed therapeuticdose, however more research needs to be completed to satisfy FDA requirements prior to initiation of clinical testing.