If an old mouse was p16 - deficient, it regrew pancreatic cells and cured itself like
a normal young mouse.
Not exact matches
The team found neonatal
mice with the mutations had
normal - appearing skin, and the dry itchy skin of dermatitis did not develop until the
mice were a few months old, the equivalent of a
young adult in human years.
Then, he found that
mice lacking Klotho died
young, after developing arteriosclerosis and other age - related conditions much earlier than
normal (Science, 7 November 1997, p. 1013).
Just 11 weeks after getting a single shot of the gene therapy, 10
young mice lacking the ob / ob gene reached weight, insulin, glucose, and leptin levels comparable to
normal mice.
The drug had a potent effect — it prevented FOP extra-skeletal bone formation and also preserved limb motion and
normal bone growth in
young mice.
It restored
normal blood sugar and insulin levels in animals that already had diabetes and prevented or slowed its onset in
young mice that had not yet developed the disease.
The
mice appear
younger and more robust than comparably - aged
normal mice, have better muscle tone, and do not develop age - related tumors.
For example,
Young's research shows normally monogamous prairie voles do not develop pair bonds with their mates if their mu - opioid system is blocked; other studies have found that
mice genetically engineered to have no mu - opioid receptors do not prefer their mothers to other
mice the way
normal baby
mice do.
They found that the samples from the older
normal mice had the most diversity of their gut microbes, including Clostridia and Bacteroides bacteria not seen in the
younger mice that were still getting their nutrition entirely from mother's milk.
Next, Abadir and colleagues compared the effects of different concentrations of losartan and valsartan on
young diabetic and aged
mice during the proliferation / remodeling phase of wound healing, which involves the regrowth of
normal tissue.
Young said Celltex did a study in which it injected lab
mice with 73 times the
normal dose of 200 million cells that Celltex gives its clients, and none of the
mice died, developed toxic organs or grew tumors.
We will inject these
mice with either oxidized proteins, bacterial components, or
normal saline in a single injection when they are
young.
The present study employed Ighb scid
mice reconstituted with
normal lymphocytes from
young (2 -3-mo-old) and aged (20 -25-mo-old) donors and immunized with a protein conjugate of the hapten (4 - hydroxy -3-nitrophenyl) acetyl (NP) to determine whether the molecular changes in antibody repertoire reflect senescence in the B cells or whether they are mediated by the aging helper T lymphocytes.