Methylation
normally switches genes off, and de-methylation turns them on.
Not exact matches
Because the prion - forming protein identified in the study
normally functions as a regulator of
gene activity, the researchers say their discovery raises the possibility that when it
switches to a prion state, it could alter genetic expression and bacterial behavior.
The new
gene permanently
switched on a set of
genes normally affected by insulin and involved in the immune system.
The two
genes implicated — GNAQ and GNA11 — code for proteins (known as G proteins) that
normally function as molecular on - off
switches, regulating the passage of information from the outside to the inside of a cell.
But what did change:
genes that during development would
normally cause the loss of connections between neurons were
switched on again in the aging astrocytes.
When they had a closer look into the embryos, the team found that several important developmental
genes that are
normally switched off during early embryogenesis were turned on in embryos without H3K27me3.
The researchers engineered a strain in which a Synechococcus
gene normally turned on during photosynthesis signals its activity by
switching on the
gene for luciferase, an enzyme from another bacterium that drives a light - emitting chemical reaction.
This was attributed to «recombination» taking place between the marker and the actual
gene during the formation of gametes (sperm and eggs), resulting in the marker
normally associated with the mutant
gene and that associated with the normal
gene being «
switched over».