Sentences with word «normoxic»

Although the fluorescent dye detached from the degraded POL - N probe stayed for some time in normoxic cells, the intact POL - N probe rapidly disappeared from the circulation and excretory organs, including the kidney and liver, dramatically reducing off - target BRET signals because they are generated from only intact POL - N, and thus increasing tumour / muscle and tumour / kidney signal ratios (Figure c).

Of the 119 genes upregulated following hypoxia, 72 % remained upregulated after a 24 h period of recovery under normoxic conditions.

In normoxic cells, the transcription factor HIF - 1α is degraded by the action of E3 ubiquitin ligase on the oxygen - dependent degradation domain (ODD) of HIF - 1α; however HIF - 1α is stabilized and therefore, accumulates in hypoxic cancer cells.

As compared to normoxic controls, a statistically significant enrichment of 5.9-fold (χ2 = 7.750, p = 0.0054, 2 - tailed) was found in hypoxic retinas and 6.3-fold (χ2 = 8.432, p = 0.0037, 2 - tailed) was found in recovery retinas.

Some rats were sacrificed at this time, and others were allowed to recover for 24 h under normoxic conditions.

However, the offspring of these adults, when reared in hypoxic conditions showed less ability to regulate their oxygen uptake and were significantly smaller than those of normoxic parents, potentially because they were having to expend more energy simply to survive in those conditions.

Furthermore, these results also have an important prognostic value — the positioning of macrophages in hypoxic tumor regions would be an indication of a poor prognosis, while the localization of macrophages in normoxic regions of the tumor could predict a better disease outcome.

It is interesting that the balance of redox modulation of vascular tone, imposed by the O2 • −: NO ratio, may be tipped in either direction to promote disequilibrium, as maternal treatment with vitamin C in normoxic pregnancy also promoted endothelial dysfunction.

Therefore, a protein containing the ODD would be intact in hypoxic tumours, but destroyed in normoxic tissues.

IANTD offer a range of Technical diving courses including Normoxic Trimix and Advanced Recreational Trimix, on Open Circuit and Closed Circuit Recreather (CCR).

Thus, the majority of the gene expression differences observed persisted for a significant period of time after return to normoxic conditions.

Alternatively, following normoxic and hypoxic culture, cells were plated in nonadherent culture for 16 hours and RNA was harvested from the CSC - enriched cells (termed anoikis - resistant (AR) population; Supplementary Fig.

Further data reported in this study show that maternal treatment with vitamin C increased birth weight in both normoxic and hypoxia pregnancy.

Retinas recovering from hypoxia also showed distinct patterns of gene expression that were different from both normoxic control retinas and hypoxic retinas, indicating that hypoxia initiates a complex pattern of gene expression.

The normoxic cells did not generate BRET signals because POL - N was recognized through the ODD and degraded by the E3 ubiquitin ligase.

These results suggest that low - intensity resistance exercise in the hypoxic condition caused greater metabolic and hormonal responses than that in the normoxic condition.

Eight male subjects participated in 2 experimental trials: (a) low - intensity resistance exercise while breathing normoxic air (normoxic resistance exercise [NR]-RRB-, (b) low - intensity resistance exercise while breathing 13 % oxygen (hypoxic resistance exercise [HR]-RRB-.