Sentences with phrase «not in normal mice»

In those mice, but not in normal mice, they found that caerulein caused existing alpha cells in the pancreas to differentiate into insulin - producing beta cells.

Not exact matches

Khabib is a damn monster and considered # 1 in the division despite not having a belt due to his own problems, not just a normal # 1 ranked guy but a Mighty Mouse or Jon Jones kind of # 1.

The team found neonatal mice with the mutations had normal - appearing skin, and the dry itchy skin of dermatitis did not develop until the mice were a few months old, the equivalent of a young adult in human years.

Even in the first week after an election, the Whitehall agents of the 800 lb gorilla of executive power are hard at work on the tiny but irritating squeak of the parliamentary mouse rather than fixing the broken democracy in partnership with parliament, «back to normal working» is not the slogan that will restore the reputation and capability of our democracy.

These mice performed better than their normal counterparts on learning tests well into old age, and their brains did not exhibit the decline in neurogenesis typically seen in aged mice.

Both mouse and human males typically die early from the mutation in Mecp2, because their Y chromosome does not supply a normal copy of the gene.

In some ways, genetically normal littermates behave like mice that carry an autism - related mutation, despite not having the mutation themselves, scientists report.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

For this study the researchers targeted very specific types of GABA receptors to improve social behaviors with clonazepam, but the team also found that by using a different drug, they could target other GABA receptors and actually reduce the ability to socially interact in normal mice — underscoring that future medications would need to target very specific receptors so as not to diminish the drug's impacts.

Normal mice saw benefits, too: Muscles and pancreas cells healed better in middle - aged mice that got rejuvenation treatments than in mice that did not.

Clarke and colleagues compared normal mice, whose gastrointestinal tracts were teeming with bacteria, with mice bred in sterile environments, whose guts didn't contain any microbes.

«The challenge is finding targets that exist on other types of cancer cells but not on normal cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who worked with Porter on testing the treatment in mice.

In those normal mice, A-beta levels weren't as high as they were in the mutated mice, but the fact that they existed was notable, says study coauthor Weihong Song of the University of British Columbia in VancouveIn those normal mice, A-beta levels weren't as high as they were in the mutated mice, but the fact that they existed was notable, says study coauthor Weihong Song of the University of British Columbia in Vancouvein the mutated mice, but the fact that they existed was notable, says study coauthor Weihong Song of the University of British Columbia in Vancouvein Vancouver.

In a study published October 30 in Neuron, the scientists show that mice genetically altered so they don't produce serotonin didn't scratch as much as normal mice when exposed to irritantIn a study published October 30 in Neuron, the scientists show that mice genetically altered so they don't produce serotonin didn't scratch as much as normal mice when exposed to irritantin Neuron, the scientists show that mice genetically altered so they don't produce serotonin didn't scratch as much as normal mice when exposed to irritants.

The authors said that this result suggests that the reason bacterial numbers are so high in these mice, and, by extension, human LAD patients, is not because of a defect in the immune system's surveillance mechanism but because of the inflammation caused by the immune system's abnormal response to normal levels of bacteria in the gums.

However, when the researchers knocked out SIRT1 in endothelial cells of 10 - month - old mice, then put them on a four - week treadmill running program, they found that the exercise did not produce the same gains seen in normal 10 - month - old mice on the same training plan.

Because mice lacking both genes would not be born alive, the scientists followed up this lead by making «conditional knockout mice,» in which Esrp1 and Esrp2 activity was normal early in fetal development, but then was switched off in skin epithelial cells.

At first, when the genetically modified mice were put in a sterile, germ - free environment, they did not develop MS.. When exposed to a normal environment that would normally contain bacteria, the mice did develop MS - like disease and inflammation in their bowels, suggesting gut bacteria is a risk factor that triggers MS disease development.

By contrast, these females retained a normal level of social interest in other females during estrus, and in male mice when not in estrus.

The researchers found that Sp7 in normal mice was expressed only in the dental mesenchymal tissue that gives rise to odontoblasts; it was not expressed in the oral epithelium that gives rise to ameloblasts.

During her postdoctoral work, Bissell noticed that removing mammary cells from a mouse and putting them into a culture dish caused them to lose not only their normal in vivo shapes, but also their ability to secrete milk.

It restored normal blood sugar and insulin levels in animals that already had diabetes and prevented or slowed its onset in young mice that had not yet developed the disease.

Normal mice watching chronically itchy mice in other cages increased their own scratching in as little as 5 seconds, whereas mice placed near nonitchy mice didn't show any increase in scratching, researchers report in Science.

When fed a diet containing cholesterol, saturated fat, and bile acids for 3 weeks, the transgenic mice, in contrast to normal mice, did not develop a detectable increase in plasma LDL.

UBC Psychiatry Professor Dr. Weihong Song and Neurology Professor Yan - Jiang Wang at Third Military Medical University in Chongqing attached normal mice, which don't naturally develop Alzheimer's disease, to mice modified to carry a mutant human gene that produces high levels of a protein called amyloid - beta.

When they restored normal nitric oxide levels by having mice breathe in the short - lived gas — as patients have done in clinical trials — cell adhesion did not increase when oxygen levels decreased.

Exposure to low - oxygen air sends EPO levels soaring in normal mice, but these conditions did not induce a rise in the hormone in the animals without HIF - 1α, the researchers report in the 18 April issue of Cell.

Mathias Chamaillard at the University of Lille, France, and his colleagues discovered that the skin cancer drug ipilimumab isn't as effective at treating cancer in mice born without bacteria in their gut, compared with mice with normal bacteria.

Since more Cx43 means less room in the bladder, the team speculates that although normal mice didn't stop producing urine when asleep, their bladders were able to hold more due to decreased Cx43 concentrations.

DNA sequencing of sperm from the grandfather mice and their pups also revealed epigenetic marks on the gene encoding M71 that weren't seen in normal mice.

«When we stimulated D1 neurons in normal mice, we did not improve their timing»» he adds.

To overcome this hurdle, researchers genetically engineered human T cells to produce a CAR protein that recognizes a glycopeptide found on various cancer cells but not normal cells, and then demonstrated its effectiveness in mice with leukemia and pancreatic cancer.

However, treatment with 1NMPP1 after the prolonged period of seizures prevented epilepsy in the genetically altered but not the normal mice.

To determine whether normal food prompts mucosal immunity in the intestines, the research team generated a special type of mice, dubbed «antigen - free» mice that were not used in research since the 1980's.

In this study, the researchers demonstrated that when normal mice were given kynurenine, they displayed depressive behaviour, while mice with increased levels of PGC - 1a1 in muscle were not affecteIn this study, the researchers demonstrated that when normal mice were given kynurenine, they displayed depressive behaviour, while mice with increased levels of PGC - 1a1 in muscle were not affectein muscle were not affected.

Bacterial counts from rodents» poop showed that although B. fragilis did not establish lasting colonies in the mice, they did «shake up the community,» of microorganisms, bringing it closer to that of the normal mice, Hsiao says.

In the normal mice, UV treatment doubled the amount of KITLG produced, whereas the p53 knockouts couldn't produce any.

In mice with A-T, the cerebellum appears normal and they do not exhibit the obvious degeneration seen in the human braiIn mice with A-T, the cerebellum appears normal and they do not exhibit the obvious degeneration seen in the human braiin the human brain.

He notes, however, that other attempts to stimulate bone growth in mice by manipulating cell signaling proteins have produced denser than normal bones — and he's surprised that Helms's team didn't see the same.

Although muscle cells did not reduce in size or number in mice lacking a protective antioxidant protein, they were weaker than normal muscle cells, researchers from the Barshop Institute for Longevity and Aging Studies at The University of Texas Health Science Center San Antonio found.

The researchers found that in genetically - modified mice lacking Interferon - 1, who were also fed a high - fat diet, the CD8 + T cells did not produce an inflammatory response, and the mice had near normal blood sugar levels.

The researchers also showed that DENV NS1 caused similar levels of blood vessel leak in normal mice as in mice bred to have inhibited cytokine activity, suggesting that cytokines were not necessary for this effect.

Light stimulation did not boost the number of spines in normal mice or strengthen the fear memory, nor did indiscriminately shining light in the dentate gyrus result in any long - term memory improvement.

They found that the samples from the older normal mice had the most diversity of their gut microbes, including Clostridia and Bacteroides bacteria not seen in the younger mice that were still getting their nutrition entirely from mother's milk.

In two separate novel - object recognition tests, the CA2 - deficient mice showed a normal preference for an object they had not previously encountered, showing that the mice did not have a global lack of interest in noveltIn two separate novel - object recognition tests, the CA2 - deficient mice showed a normal preference for an object they had not previously encountered, showing that the mice did not have a global lack of interest in noveltin novelty.

The drug wasn't as effective at treating cancer in these mice compared with mice with normal gut bacteria.

The concentrations used in mice weren't justified or explained what the equivalent levels would be in humans i.e. is 50mg / kg the dose expected to be the safe / normal levels in humans?

Another behavior that scientists have observed in Huntington's disease model mice is that they aren't as motivated as normal mice to drink sweet water.

In Yeast, Worms, Flies, and Mice, Only About 1 in 3 Genes is Essential for Viability The consequences of some genomic perturbations can not be compensated for by normal epigenetic processes and result in the death of the organism prior to adulthooIn Yeast, Worms, Flies, and Mice, Only About 1 in 3 Genes is Essential for Viability The consequences of some genomic perturbations can not be compensated for by normal epigenetic processes and result in the death of the organism prior to adulthooin 3 Genes is Essential for Viability The consequences of some genomic perturbations can not be compensated for by normal epigenetic processes and result in the death of the organism prior to adulthooin the death of the organism prior to adulthood.

Results showed the first two groups didn't develop PCOS, unlike the mice in the control group, whereas the test subjects with ovary ARs still contracted the disease, albeit at a lower rate than the normal mice.