Remember we're talking about normal,
not mutant huntingtin here.
Not exact matches
The VCP inside mitochondria only interacted with
mutant, but
not healthy
huntingtin protein.
The international team of scientists from University College London, IRBM Promidis, University of British Columbia, and CHDI Foundation developed a new ultra-sensitive test using the Singulex SMC Technology Erenna Immunoassay system that is able to detect
mutant huntingtin in the cerebrospinal fluid (CSF) of HD patients, including some who carry the HD mutation but have
not yet developed symptoms.
«We don't know exactly how the
mutant Huntingtin gene causes the disease, so the idea is that targeting the gene expression cuts off the problem at its source — preventing it from ever having the potential to act,» said Dr Isalan.
Juliette Gafni, Theodora Papanikolaou, Francesco DeGiacomo, Jennifer Holcomb, Sylvia Chen, Menalled L.; Kudwa A.; Jon Fitzpatrick, Miller S.; Ramboz S.; Pasi Tuunanen, Kimmo Lehtimaki, Xiangdong William Yang, Seung Kwak, Larry Park, David Howland, Hyunsun Park, and Lisa Ellerby Caspase - 6 activity in a BAC HD mouse modulates steady state levels of
mutant huntingtin protein but is
not necessary for production of a 586 amino acid proteolytic fragment.
Note: these mice don't produce toxic
mutant huntingtin protein.
First things first - the news that IONIS - HTTRx lowers the
mutant huntingtin protein is great - but it is
not a cure.
That's
not what we expect when patients are given
huntingtin - lowering drugs, which might produce around 50 - 75 % reductions in the
mutant and healthy protein.
Gafni J, Papanikolaou T, DeGiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen P, Lehtimaki K, William YX, Kwak S, Park L, Howland D, Park H, Ellerby L.Caspase - 6 activity in a BACHD mouse modulates steady - state levels of
mutant huntingtin protein but is
not necessary for production of a 586 amino acid proteolytic fragment.