Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but
not normal breast tissue.
Not exact matches
In some cases, a girl's
breasts may grow during puberty, but perhaps that growth is asymmetrical (uneven) or the
breasts are large and appear
normal, but only fatty
tissue develops,
not glandular
tissue.
The 5E5 antibody recognized multiple types of cancer cells, including leukemia, ovarian,
breast, and pancreatic cancer cells, but
not normal tissues.
The news wasn't all bad: When Fischbach's team put obese mice on a diet, their mammary fat
tissue had fewer myofibroblasts, suggesting losing weight could make a woman's fat
tissue structure more
normal and lower her
breast cancer risk.
Interestingly, the team found that radiologists could do better than chance in discriminating
breast cancer cases from
normal tissue, even when the images of abnormal
breast tissue did
not directly capture a cancerous lesion or when those images were taken from the contralateral
breast (the
breast on the other side of the body) of a woman with
breast cancer.
(A) MELK expression levels are significantly higher in
breast carcinoma (
n = 392, red circles) than in
normal breast tissues (
n = 61, blue circles) in the TCGA
breast cancer cohort (Cancer Genome Atlas Network, 2012).
Our bioinformatics analysis, based on multiple independent large - size cohorts shows that MELK is strongly overexpessed in BBC / TNBC,
not only compared to
normal breast tissues, but also compared to luminal or ER / PR +
breast cancer.
If you're wondering what a cancer lump feels like, know that most of the time lumps are
not cancer — in fact,
normal breast tissue can feel lumpy too.
If your hormone levels are
normal, it's possible that your
breast tissue is simply overly sensitive to estrogen and / or
not sensitive enough to testosterone.
Mammary tumor virus sequences have
not been detected in
normal breast tissue or other tumors.