Sentences with phrase «not sustained over time»

Or is aptitude merely «potential» if effort and interest are not sustained over time?

We can't sustain this over time; it's environmentally and financially unsustainable.»

Not exact matches

He's since pointed out that the popular understanding of this maxim is generally oversimplified, but that doesn't undermine the essence of the argument — sustained effort over time is a hallmark of greatness.

He added that they fear they won't have the same levels of capital to back the best startups over a sustained period of time.

The research suggests that the achievement of difficult goals entails not only talent but also the sustained and focused application of talent over time.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Assuming that you won't get paid for your time off, you might want to have some money set aside to sustain yourself over the break.

But people like Buffett and Porter believe it isn't enough to reliably sustain profitability over long periods of time.

While a return of 1 % + might not seem like a lot, this will compound over time and give me an advantage over the market if I can sustain these gains.

Friendship sustains pastors over time and not simply during crises — it is the kind of collegiality that is crucial to the cultivation of self - knowledge, relational intelligence, the capacity to remain dynamically engaged with one's work and the ability to identify and negotiate conflict, all of which are relevant to preventing the dynamics that cause clergy to leave pastoral ministry.

well just thinking about these wars in the muslim / mid-east world over religious differences (which may reflect mental states in many ways) in a world where most realize that living in the present moment is best way to happiness and being in the moment in non-strife and awareness through the teachings of masters such as found in the buddhist, taoist, zen, etc., etc., etc. spriritually based practices of religious like thought and teachings, etc. that to ask these scientifically educated populace whom have access to vast amounts of knowledges and understandings on the internet, etc. to believe in past beliefs that perhaps gave basis and inspiration to that which followed — but is not the end all of all times or knowledges — and is thus — non self - sustaining in a belief that does not encompass growth of knowledge and understanding of all truths and being as it is or could be — is to not respect the intelligence and minds and personage of even themselves — not to be disrespected nor disrespectful in any way — only to point out that perhaps too much is asked to put others into the cloak of blind faith and adherance to the past that disregards the realities of the present and the potential of the future... so you try to live in the past — and destroy your present and your future — where is the intelligence in that — and why do people continually fear monger or allow to be fear — mongered into this destructive vision of the future based upon the past?

Some readers will doubtless complain that this conservatism is too Romantic, too English, one that can not be sustained over the course of a life, and certainly not in times of crisis or moral and social decay.

Despite his «reformed subjectivist principle,» Whitehead does not, in my opinion, adequately address such high level human experiences as responsibility and our sense of a sustained «being - here» over time.

Food is not fixed in time, yet we have been poor managers of our resources over the years as human civilization has progressed and today stand at a situation where sustaining our biggest source of energy has transformed into our biggest problem coupled with environmental degradation.

There remains a need for future research to particularly show the effects of sustained or longer - term exposures to food advertising and to test whether the observed increases in intake after acute exposures are not later compensated for and, therefore, could lead to weight gain over time (54).

A bad game by the match officials doesn't gloss over Wenger's and the teams in adequacies in my opinion over a sustained period of time but of course why does that matter when we as fans are told by Ivan we're punching above our weight, the club, our club has so many problems its scary but bad linesman and refs we can't.

According to The Sun, the 24 - year - old is «in a race against time to be fit» having sustained a hamstring injury last weekend in the win over Liverpool, and so Tottenham will have to carefully monitor him in the next 24 hours to determine whether or not he can feature against the Red Devils at Old Trafford.

Finding a way to reconcile two competing demands - minimizing contact in practice in order to reduce the number of concussions sustained and the number of hits players sustain over the course of a week and a season that emerging science, now more than ever, suggests may have a deleterious cumulative effect [26] on a player's cognitive function over the long term, while at the same time maximizing the amount of time in practice learning how to tackle and block without head - to - head contact - time that is needed to maximize the protective effect of proper tackling on the number of head - to - head hits players sustain in game action, which can not only result in concussion, but catastrophic neck and spine injuries - is challenging, but clearly not impossible.

Investment in north England will require sustained attention over a long period of time, not just one short announcement.

I hope those Fabian members and other Next Left readers who are not already part of the Avaaz network will look at getting involved in this campaign and the other initiatives and campaigns: the case for sustained and positive civic pressure over time is massively important in between the big summits which hit the headlines.

But the mayor warned that the city's budget might not be able to sustain such outlays over time.

«Many people are excited by the potential of using activity trackers to monitor healthy behaviors, but there is very little evidence on who is using them and whether or not use is sustained over time,» said Mitesh Patel, MD, MBA, MS, an assistant professor of Medicine and Health Care Management, and director of Penn Medicine's Nudge Unit.

The program can not be sustained over time without those motivated and hardworking teachers.

But the study looked at departures from average conditions over shorter time periods, and may not be a good indicator of how people will respond to sustained warming.

«A sustained increased heart rate of over 100 beats per minute could mean there is not enough time for the heart to fill properly, leading to a fall in the volume of blood being pumped,» says Ann Robinson, a London - based general - practice doctor.

The reishi mushroom is well known as an immune modulator, meaning that it doesn't «boost» our immune system, but helps sustain optimal function over long periods of time, which is ultimately more desirable.

Female athletes are at risk for common nutrient deficiencies, such as low protein, low iron, low calcium, and low vitamin D. (3) When active women don't eat enough nutrients, or they are poorly absorbed due to increased intestinal permeability (leaky gut), SIBO, SIFO, or other causes of intestinal epithelial inflammation, they are not nourished enough to sustain intense exercise over time.

Fruit contains certain nutrients ie antioxidants, various vitamins a, c etc but grains contain other nutrients that help regulate homeostasis such as chromium, b vitamins, and whole grain starches that are converted slowly over time sustaining energy levels and not spiking up blood sugar levels (compared to fruit) quickly then dropping it.

However, having said that, the diet does not ask you to sustain your commitment over a long period of time.

While some herbs or flowers may be used to brew KT in the primary fermentation, they don't contain enough of what the culture needs to sustain itself over time.

Previous studies suggest that sensitivity to caffeine may be lost over time, which means that body weight regulation can not be sustained for a longer period of time while receiving the same dosage.

It means well and tries hard but it simply doesn't have enough er, flesh to work over a sustained time and quickly feels tired.

And while Landline portrays characters grappling in their own ways with the age - old institution of marriage and the expectations of monogamy it creates, Robespierre isn't cynical about romantic relationships, recognizing the need for constant companionship, while acknowledging the at - times - agonizing difficulties in sustaining them over a long period of time.

At over two hours, there is a little too much time and not enough plot to sustain a sense of momentum.

The authors conclude that achieving difficult goals involves not only talent but also sustained and focused application of talent over time.

All of these outcomes, however, are measured in the short run, and might not be sustained over time.

The focus of the project was to further develop the concept of a language challenge, in which teachers, students and businesses worked together not for a day, but over a sustained period of time.

Applying effort over a sustained period: Education systems that have not been designed to recognise and respond to the needs and contexts of Indigenous students will take time to adjust.

If you don't have a mechanism to renew your enthusiasm or at least sustain it and keep it going, then over time your organisational capacity will diminish — and the same is true for principals and teachers personal capacity to keep pace with educational change.

The economic analysis allowed for the possibilities that 50 % of the improvement in a young person's mental health would either have occurred anyway, since some children will recover without counselling support, or that their recovery might not be sustained over time.

Wilbur Rich, a professor emeritus of political science at Wellesley College in Massachusetts, said he wouldn't call any of the experiments with mayoral control a success - not until the gains are larger or sustained over a longer time.

Implementing these strategies does not come easily, but they can produce positive results with sustained effort and support of teachers over time.

By contrast, top - down efforts that don't involve close work over sustained periods of time with the communities in question over time are doomed to fail, as the state's own experience shows, Mr. Sciarra argued.

As the experiences in these two states illustrate, though, the challenge is not to design and implement programs to strengthen the teaching profession — the real challenge is to sustain such supports over time.

He asserts that while «Great books» change or decline in cultural relevancy over time, «the joy and benefit of a sustained narrative — rendering a virtual world in your mind — won't go away.»

It's still great to get a big X of sales over a short Y amount of time, but Amazon likes sales consistency, not stabs in the dark that can't be sustained.

But this doesn't mean you can't achieve good sales over time with a sustained and strategic media outreach plan.

The chemical process through which it's created allows the steel to sustain different types of weather and not crumble over time.

After all, dealers and artists alike used to consider premature auction - market debuts a terrifying prospect for emerging talent, because it can either spike their primary market prices to a height that can't be sustained over time by still - immature work, or worse, present an opportunity for an embarrassingly public flop.

It seems hardly any country in the world has moved the decarbonization rate upwards by 1.3 % over a sustained period of time, and the one major economy that may have done so (the UK) has gone through a coal - to - gas transition that can't be repeated, while de-industrializing at the same time.