In a study presented in the featured clinical investigation article of the November issue of The Journal of Nuclear Medicine, they used 18F - fluorodeoxyglucose (FDG) PET / CT imaging to show that the amount of cell - free tumor DNA circulating in the bloodstream correlates with tumor metabolism (linked to cancer aggressiveness),
not tumor burden (amount of cancer in the body).
Not exact matches
The approach was most successful in making a difference in samples from the two patients in which the smaller - sized
tumor DNA was
not readily apparent, which may represent patients with low
tumor burden and previously difficult to detect circulating
tumor DNA.
«The traditional staging system does
not account for the total volume of disease or baseline
tumor burden,» Dr. Joseph says.
4) The planned comparison of
tumor burden from mice treated with (+)- JQ1 compared to vehicle control was
not statistically significant, nor was the planned comparison between (+)- JQ1 treatment and -LRB--)- JQ1.
Three weeks later, there was no detectable difference in
tumor frequency or
burden between Atg7 - intact or Atg7 - deleted mice, suggesting that autophagy may
not be required for
tumor initiation in this case.
In advanced mammary cancers where metastasis has occurred or in which the
tumor is fixed to the underlying tissues, surgery will
not be curative but may be considered an option to reduce local
tumor -
burden and improve quality of life.