Sentences with phrase «not whole genome sequencing»

With all due respect, if you'd read the actual study, you would see that this was not a whole genome sequence comparison; rather it was a comparison of mitochondrial 12S rDNA and 16S rDNA sequences for the purposes of confirming the species relationship between the Pod Mrcaru lizards (P. sicula), the source population from Pod Kopiste (also P. sicula), and the original indigenous population on Pod Mrcaru (P. mellisellensis).

Not exact matches

This time Venter turned to Diamandis (Page had introduced them) not because of a failure at the NIH but because financiers weren't supporting companies that did whole - genome sequencing.

Regarding the Pod Mrcaru lizards: I am aware that researchers didn't make a whole genome sequence comparison.

Meanwhile, technology limits the impact of the Supreme Court ruling: The falling price of whole - genome sequencing, which sidesteps patents altogether because it doesn't require isolating a gene, makes it a reasonable alternative to a patented BRCA - style test.

So even though some of the leaders of the 2014 avian tree effort launched B10K, a project aiming to eventually sequence the whole genomes of all 10,560 bird species and from there build «the grand tree,» some bird researchers decided not to wait.

He argues that whole genomes will not only provide more data for building trees, but will also enable researchers to study the evolution of regulatory sequences, transposable elements, and other aspects of the genome that are not covered with OpenWings sequencing.

«These predictive algorithms seem to do a good job when CRISPR is performed in cells or tissues in a dish, but whole genome sequencing has not been employed to look for all off - target effects in living animals,» says co-author Alexander Bassuk, MD, PhD, professor of pediatrics at the University of Iowa.

«Researchers who aren't using whole genome sequencing to find off - target effects may be missing potentially important mutations,» Dr. Tsang says.

However, Manogue said it's not clear that whole - genome sequencing infringes on the rights of gene patent holders.

Other contenders have until May 2013 to sign up, but «a lot of companies are not focusing on whole genome sequencing,» says Campany.

This time Venter turned to Diamandis (Page had introduced them) not because of a failure at the NIH but because financiers weren't supporting companies that did whole - genome sequencing.

I was one of the first people to have his whole genome sequenced, but we still can't tell very much about me from my genome.

«Even a few years ago, I didn't imagine it would be possible to sequence the whole Neanderthal genome,» he says.

«We're not saying there's no point» to whole - genome sequencing, says Vogelstein, who presented the findings here today at the annual meeting of the American Association for Cancer Research.

Even though it should be possible to sequence a fetus's whole genome, Lo says, it might be better to do it in a targeted fashion so that information doesn't overwhelm prospective parents.

The findings not only validate the systematic approach to whole - genome sequencing in clinics, they also demonstrate that de novo mutations, otherwise known as spontaneous mutations not inherited by parents, are the main cause of this severe type of epilepsy.

First of all, only the metastatic sample was whole - genome sequenced — the primary tumor and matched normal were not.

The most significant of these was the HiSeq X Ten, a 10 - instrument «factory installation» that enabled the most cost - effective human whole genome sequencing to date: 18,000 genomes per year at a consumables cost of just over $ 1,000 each (note: this does not include the costs of data storage, analysis, or the $ 10 million buy - in).

This project indicated that not only a vast number of novel potentially functional variants in a total of 231 pharmacogenes was identified but also demonstrated the value of whole - genome sequencing for pharmacogenomic testing by capturing over 18,000 variants per individual in these pharmacogenes.

By comparing the whole genome sequence of the lab - cultured resistant strain with a sibling strain that had not been exposed to the drug, they were able to identify several mutations of interest in a number of genes.

The study utilized SNP data from several sources including Illumina SNP chip genotyping as well as whole - genome sequencing of 7 Icelanders with SSS and 80 Icelanders not diagnosed with SSS.

She said the findings underscored the importance of sequencing the whole genome, not just the protein - coding regions — or exome — to identify the mutations driving cancer in children.

As our understanding of the noncoding portion of the genome improves, it will become even more apparent that whole - genome sequencing (and not exome sequencing) will be required to characterize the full extent of phenotypically - relevant genetic variation in humans.

Whole mitochondrial genome sequences of mammoth specimens spanning over 50,000 years have shown that mammoths not only migrated from Asia to North America, but back again.

Whole - genome sequencing is becoming commonplace, but the accuracy and completeness of variant calling by the most widely used platforms from Illumina and Complete Genomics have not been reported.

In this study, using whole - genome DNA sequencing (WGS) and confirmation by Sanger sequencing, we observed mutations identified in several genes not previously known to be recurrently altered in SMZL.

Sequencing on this scale would not be possible without the IT and informatics infrastructure, built under the leadership of David Dooling and Gary Stiehr, that gives us the computational firepower to run whole - genome analyses.

Whole Genome Sequencing Not Informative for All A study involving data of thousands of identical twins by Johns Hopkins investigators finds that whole genome sequencing fails to provide informative guidance to most people about their risk for most common diseases, and warns against complacency born of negative genome test resWhole Genome Sequencing Not Informative for All A study involving data of thousands of identical twins by Johns Hopkins investigators finds that whole genome sequencing fails to provide informative guidance to most people about their risk for most common diseases, and warns against complacency born of negative genome test reGenome Sequencing Not Informative for All A study involving data of thousands of identical twins by Johns Hopkins investigators finds that whole genome sequencing fails to provide informative guidance to most people about their risk for most common diseases, and warns against complacency born of negative genome tesSequencing Not Informative for All A study involving data of thousands of identical twins by Johns Hopkins investigators finds that whole genome sequencing fails to provide informative guidance to most people about their risk for most common diseases, and warns against complacency born of negative genome test reswhole genome sequencing fails to provide informative guidance to most people about their risk for most common diseases, and warns against complacency born of negative genome test regenome sequencing fails to provide informative guidance to most people about their risk for most common diseases, and warns against complacency born of negative genome tessequencing fails to provide informative guidance to most people about their risk for most common diseases, and warns against complacency born of negative genome test regenome test results.

This is a landmark study not only due to the size, but the systematic characterization of each case using whole - genome sequencing (WGS), exome sequencing (WES), and transcriptome sequencing (RNA - seq).

Whole genome sequencing is powerful but can not detect all types of genetic variation that may contribute to or cause disease.

Re-analysis costs are not included in the price for whole genome sequencing through the

The new article, yet to be peer - reviewed or published, concludes, «Taken together, these whole - genome - sequencing - level results support the idea that in specific cases, CRISPR - Cas9 editing can precisely edit the genome at the organismal level and may not introduce numerous, unintended, off - target mutations.»

In our comparison, we did not consider practical parameters such as the required amount of DNA input, sequencing costs, or time required to complete a whole genome sequencing run (Table S1).

«Especially with what's called next generation sequencing or whole genome sequencing where it's not just one patent holder you have to deal with there is a real fear Canadian hospitals and researchers will be locked out of this domain and it could hurt us in terms of delivery of the service, health - care costs, and being locked out of innovation — those were the three important things at stake,» says Gold.