The researchers thus shed light to a complex disease by
suggesting novel candidate genes as well as presenting a new method for analyzing a trait based on a continuous variable (in GWAS).
Richarda Voer and colleagues report a study
on novel candidate genes for colorectal cancer (CRC) at an early age in life.
In previous studies, Hu and her group reported that RORA is
a novel candidate gene for autism and is regulated in opposite directions by male and female hormones.
The researchers particularly identified three
novel candidate genes; KIRREL3 and SLIT1, with documented roles in immune cell development, and SERPINA9 expressed exclusively at the site (germinal center) where a B - cell starts producing IgA.
Novel candidate genes have been identified and the results are published in PLOS ONE.
We then use a range of techniques to validate the role of
the novel candidate genes in the development of cancer.
Despite type 2 diabetes having been well studied by genome - wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as
a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.
Friday, Oct. 20, 5:30 - 5:50 p.m., South Hall B, South Building Featured Plenary Abstract: The contribution of rare variants, polygenic risk, and
novel candidate genes to the hereditary risk of breast cancer in a large cohort of breast cancer families N. Li, Peter MacCallum Cancer Center, et al