Sentences with phrase «novel cell and gene»

A physician with a longstanding interest in gene therapy, Dr. High was formerly a Professor at the Perelman School of Medicine of the University of Pennsylvania, an Investigator of the Howard Hughes Medical Institute, and the Founding Director of the Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia, a Center focused on developing novel cell and gene - based therapies for genetic disease.

Dr. Levine directs the Clinical Cell and Vaccine Production Facility (CVPF), which develops, manufactures, and tests novel cell and gene therapies in clinical trials at Penn and collaborating institutions.

Not exact matches

M. J. Bertram et al., Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor - like genes.

Novel abnormalities in the FGFR gene, called FGFR fusions, were identified in a spectrum of cancers, and preliminary results with cancer cells harboring FGFR fusions suggested that some patients with these cancers may benefit from treatment with FGFR inhibitor drugs, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.

«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.

Monsanto's newest drought - tolerant product, Drought Guard, relies on a gene that creates a chaperone protein to coat a plant's RNA during stressful conditions and maintain the plant's normal cell functions, while Syngenta's hybrid contains novel drought - tolerant gene combinations.

By identifying novel genes and molecular pathways involved in shaping a taste cell's function, these findings may someday allow scientists to treat taste disorders, characterize new taste qualities, or even fine - tune a person's taste perception to encourage healthier eating.

Using novel technologies developed at HMS, the team looked at how a single sensory experience affects gene expression in the brain by analyzing more than 114,000 individual cells in the mouse visual cortex before and after exposure to light.

«In addition to known disease - related genes, we have discovered seven novel genes as the cause of X-linked intellectual disability and analysed what signaling pathways in the cells each protein is involved in,» says Kalscheuer.

Inflammation response induces the transcription of the Irg1 gene and enhancer RNAs, causing the emergence of novel enhancer regions and a novel enhancer landscape within a cell.

Given his training in developmental biology, Raman focused the team to seek a novel drug target on genes important to the development of model organisms — fruit flies (Drosophila) and yeast (Saccharomyces cerevisiae)-- rather than on oncogenes that transform a normal cell into a cancer cell.

The group took the first step toward their goal of a novel engineering strategy for yeast by creating what is known as a cDNA library: a collection of over 90 % of the genes from the genome of baker's yeast (Saccharomyces cerevisiae), arranged within a custom segment of DNA so that each gene will be, in one version, overactive within a yeast cell, and in a second version, reduced in activity.

However, coreceptor - specific ZFNs represent a novel therapeutic approach to recapitulate this success via autologous transplantation of gene - modified hematopoietic stem cells and mature CD4 + T cells.

Use of exon - based transcriptome profiling to identify novel signaling pathways and survival - associated genes in diffuse large B - cell lymphoma.

Using a novel technique to genetically modify T cells for adoptive transfer, Carl June, Michael Kalos, David Porter, Bruce Levine, and colleagues at the University of Pennsylvania School of Medicine achieve clinical responses in patients with chronic lymphocytic leukemia, including two complete, durable (one year) clinical responses, accompanied by in vivo expansion and long - term functional persistence of gene - modified cells.

Using a novel methodology, the researchers found an association between the disorder and a DNA marker that is very close to the dopamine transporter gene, which controls the intake of this important neural messenger by the nerve cells that respond to dopamine's signal.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

A novel way of approaching protection - based therapeutics for glaucoma should derive from evidence accumulating over two decades in stroke and cardiac arrest: That simultaneously activating a variety of self - defense responses in cells with stressful «conditioning» stimuli induces the expression of a host of genes that promote cell survival.

Collaborating with the labs of Salk Professors Joseph Ecker and Alan Saghatelian, the Izpisua Belmonte team performed extensive characterization of the new cells and found rsPSCs showed distinct molecular and metabolic characteristics as well as novel epigenetic signatures — that is, patterns of chemical modifications to DNA that control which genes are turned on or off without changing the DNA sequence.

We identified and characterized a novel member of the forkhead gene family that is essential for proper regulation of satellite cells.

BRD7, a novel PBAF - specific SWI / SNF subunit, is required for target gene activation and repression in embryonic stem cells.

We will use these data to characterize novel genes that regulate the quiescent and proliferative states of β - cells.

The researchers particularly identified three novel candidate genes; KIRREL3 and SLIT1, with documented roles in immune cell development, and SERPINA9 expressed exclusively at the site (germinal center) where a B - cell starts producing IgA.

The next step based on these novel head and neck cancer discoveries, the scientists agree, is to tease out how the genes function in normal cells, whether they form the lining of the larynx, pharynx, or another anatomical site affected by head and neck cancer.

Dissertation work led to phenotypic validation of a novel gene for the scale - up and expansion of stem cells.

He is the principal discoverer of the p21 activated protein kinase (PAK) family of cell signalling proteins and of novel virulence - inducing genes in pathogenic fungi.

Using a combination of stem cells and novel analytical tools, scientists at the Wellcome Sanger Institute and their collaborators discovered that clues to the contribution of genetic variation to disease risk lie not only in the genes, but also in the molecular switches that control those genes.

Graber will also lead the development of the Comparative Models of Regeneration Database (RegenDB), a novel bioinformatics resource supported by the National Institutes of Health (NIH) whose function is to integrate gene function across multiple animal, tissue and cell models in order to validate and inform the hypotheses needed for the discovery and development of regenerative medicine drug therapies.

Dr. Bulte oversees the development of novel reporter genes that can provide contrast on MRI scans, and artificial proteins in mammalian cells that contain specific proton exchangable groups of which the proton signal can be manipulated.

Gene and cell therapies have made important medical advances over the past three decade, developing technologies and testing novel therapies in multiple human clinical trials of many diseases.

Mapping the epigenome will allow Vijay and his team to zoom in on those genes with the greatest likelihood to contribute to disease, and the cell types in which they act, and therefore will help identify novel therapeutic targets.

We have discovered multiple genes critical for generating liver and pancreas cells and have created novel animal models for diseases such as diabetes and Alagille Syndrome.

Cenix BioScience is a contract research organization focused on the discovery and pre-clinical development of novel therapeutics, specializing in advanced applications of RNA interference (RNAi) gene silencing combined with high content phenotyping in cultured cells in vitro and in animals in vivo.

The scientific goal of the Cancer Biology Program is to identify novel genomic and genetic alterations that play causal roles in cancer development and to study genes, proteins, and signaling pathways that mediate the altered phenotypes of cancer cells.

Analyzing patterns of gene expression in individual human immune system cells, the researchers refined the definitions of the types known as dendritic cells and monocytes and identified a novel type that had been overlooked.

The Kind group studies the regulation of gene expression in single cells by developing and using novel microscopy and genomics based techniques.

«Our study also highlights that growth of normal cells and cancer cells is driven by different gene switches, suggesting that further work to find ways to control the activity of such disease - specific switches could lead to novel, highly specific approaches for therapeutic intervention», says Professor Jussi Taipale, who led the study.

Talks will discuss the origination of novel cell type gene regulatory networks, and cover the latest research into the evolution of cell type functional modules, such as protein complexes and larger macromolecular structures.

We propose that genes involved in cell migration and invasion, such as fascin1, could serve as novel targets for metastasis prevention.

NYSCF — Robertson Stem Cell Investigator and NYSCF — Robertson Stem Cell Prize recipient Feng Zhang, PhD, Core Member of the Broad Institute of Harvard and MIT, shared yet another novel update of CRISPR gene editing technology.

To uncover molecular processes in individual cells and to understand the full complexity of biological systems, our lab applies and develops novel microscopy and genomics based techniques to study the regulation of gene - expression in single cells.

We use the Haplobank in reverse genetic screens to investigate the temporal resolution of essential genes in mES cells, and to identify novel genes that control sprouting angiogenesis and lineage specification of blood vessels.

Senoo M, Tsuchiya I, Matsumura Y, Mori T, Saito Y, Kato H, Okamoto T, Habu S. Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant - negative isoform, and loss of expression of the potential tumour suppressor p51.

309/5: 00 Meta - analysis of rare and common exome chip variants identifies and replicates S1PR4 and other novel genes influencing blood cell traits.

Microarray studies have the potential to piece together groups of co-regulated genes and thus lead to the discovery of novel components of genetic pathways in ES cells.

Clinical and Regenerative medicine refers to development and implementation of advanced therapeutic approaches that may involve the support of expertise in gene / cell therapy, tissue engineering, pharmacology and pharmacogenomics, development of novel molecular target therapy.