Sentences with phrase «novel cell types»

In both cases, novel cell types often evolve new or specialized functions.

The term, dendritic cell, is proposed for this novel cell type.»

Talks will discuss the origination of novel cell type gene regulatory networks, and cover the latest research into the evolution of cell type functional modules, such as protein complexes and larger macromolecular structures.

New computational strategies are supported by our single cell data analysis experts with computational methods deconvolute tissue composition, determine cell type heterogeneity, identify novel cell type defining markers or track transcriptional dynamics.

Not exact matches

When combined with other polymers, the structures could also convert light into electricity and serve as the basis for a novel type of solar cell.

«Novel type 1 diabetes treatment shown to work on human beta cells transplanted into mice.»

«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.

X-ray-like imaging without the harmful radiation and cell phones with more bandwidth are closer to reality now that researchers have developed a novel type of lens that works with terahertz frequencies.

In another novel finding, the team demonstrated that ANG achieves these dual functions by inducing RNA processing that is different in various cell types.

To determine the most common type of age - related segregation errors, the researchers first used a novel high resolution imaging technique to visualize chromosomes in live mouse egg cells throughout the whole first stage of meiosis.

Understanding stem / progenitor cells — which can develop into various types of tissue — are key to developing novel approaches for regenerative medicine.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

The study, led by Katalin Susztak, MD, PhD, a professor of Renal - Electrolyte and Hypertension and Genetics, also identified three novel cell populations, along with all previously described kidney cell types.

He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds of cancer cell lines, not just melanoma, and look for novel combinations that will benefit subsets of patients regardless of the particular type of tumor they have.

Ferroptosis is a novel, yet only partly understood, type of regulated necrotic cell death that may underlie some forms of...

Other researchers at Joslin are conducting large scale genetic screening for novel therapeutic targets to control autoimmunity, which will complement the effort of BAIRT to extend autologous beta cell replacement to patients with type 1 diabetes.

Our work focuses on discovering and characterizing novel small molecules that can control cell fate and function in numerous cell types, including stem cell maintenance, activation, differentiation, and reprogramming in various developmental stages and tissues.

Ferroptosis is a novel, yet only partly understood, type of regulated necrotic cell death that may underlie some forms of degenerative diseases including neurodegeneration but that could also be harnessed to treat certain cancers.

In this image, a novel type of human stem cell is shown in green integrating and developing into the surrounding cells of a nonviable mouse embryo.

Human iPS cell - derived hepatocytes differentiated with our robust differentiation protocol and cultured using our novel maintenance medium provide an inexhaustible, consistent supply of functional hepatocytes that can be used to advance the understanding of diseases related to dysfunction in liver metabolism, including NAFLD / NASH, type 2 diabetes, and metabolic syndrome.

Kriegstein said the identification of hundreds of novel biomarkers for diverse cell types will improve scientists» understanding of the emergence of specialized neuronal subtypes.

«We have identified novel molecular features in diverse cell types using a new strategy of analyzing hundreds of cells individually,» said Arnold Kriegstein, MD, PhD, director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at Ucell types using a new strategy of analyzing hundreds of cells individually,» said Arnold Kriegstein, MD, PhD, director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCell Research at UCSF.

Human iPS cell - derived hepatocytes differentiated with our robust differentiation protocol and cultured using a novel maintenance medium provide an inexhaustible, consistent supply of functional hepatocytes that can be used to advance the understanding of diseases related to dysfunction in liver metabolism, including NAFLD / NASH, type 2 diabetes, and metabolic syndrome.

Researchers from the Sloan - Kettering Institute, led by Dr. Lorenz Studer, have discovered a novel type of neural stem cell, which has a broader differentiation potential than previously identified neural stem cells.

«An exciting outcome of this study was the allocation of known and novel specific sensory molecules associated with each epithelial cell type,» said Rogel.

With the help of conditional and function - selective knockout mice for the glucocorticoid receptor (GR) the lab identified critical cell types and novel mechanisms for anti-inflammatory activities of glucocorticoids in different inflammatory disease models.

«Identification Of A Novel Neural Stem Cell Type.»

We invite original innovative research on the rational engineering of plant systems at all levels, including proteins, protein complexes, sensors, metabolic and signalling pathways, microcompartments such as carboxysomes, subcellular compartments, cell types or tissues, as well as the engineering of novel plant hybrid species and the interactions of plants with viruses, bacteria, and other organisms.

He has developed novel cellular models of neurological diseases (schizophrenia, MS, autism, Alzheimer's, Parkinson's) using human induced pluripotent stem cells (iPSCs) derived from donor patients and differentiated to specific neuronal cell types.

The collection of protocols includes the isolation and maintenance of stem cells from various species using «conventional» and novel methods, such as derivation of ES cells from single blastomeres, differentiation of stem cells into specific tissue types, isolation and maintenance of somatic stem cells, stem cell - specific techniques and approaches to tissue engineering using stem cell derivatives.

Such analyses will be based on novel genomic, transcriptomic and epigenetic datasets generated for all mature blood cell types and their precursors by the EU - funded BLUEPRINT project.

Cancer Institute research highlights include innovative studies to develop individualized approaches for treatment and prevention of lung cancer; collaboration between medical and materials science researchers to develop treatments for various types of leukemia using nanotechnology to target only cancer cells; and development of novel therapeutics to treat metastatic melanoma using an approach that regulates the processes leading to tumor development.

To replicate the cell interactions in the developing heart, the scientists developed a novel method of growing two distinct cell types together.

To define the relationship between neuropeptide signaling and aging, we are developing novel approaches for cell - type - specific analysis of neuropeptide signaling in the worm and the mouse.

Mapping the epigenome will allow Vijay and his team to zoom in on those genes with the greatest likelihood to contribute to disease, and the cell types in which they act, and therefore will help identify novel therapeutic targets.

In the lab for Human Brain and Neural Stem Cell Studies we aim at developing experimental paradigms to systematically identify novel types of neural stem and progenitor cells that serve as building blocks for brain development.

Many of the novel motifs displayed occupancy patterns that were highly cell - type - specific, similar to the patterns observed among major developmental and tissue - specific regulators.

But novel genomic tools are beginning to reveal new, rare cell types as well as unexpected variability and plasticity within groups upending the traditional view of immune cells assigned to the same category as unvarying entities that behave in a constant manner.

Analyzing patterns of gene expression in individual human immune system cells, the researchers refined the definitions of the types known as dendritic cells and monocytes and identified a novel type that had been overlooked.

This work is part of a newly funded U.S. Department of Energy / Department of Agriculture project led by the University of Missouri, Columbia to explore the biology of a single plant cell type, while gaining novel insight into the impacts of temperature and water availability on a crucial root cell necessary for nutrient uptake.

San Diego, August 1, 2017 — ViaCyte, Inc., a privately - held, leading regenerative medicine company, announced today that the first patients have been implanted with the PEC - Direct ™ product candidate, a novel islet cell replacement therapy in development as a functional cure for patients with type 1 diabetes who are at high risk for acute life - threatening complications.

Using mouse genetics in combination with novel sequencing technologies our lab is able to identify key cell types or candidate factors important for specific remodeling and repair processes of the heart.

The observations that astrocytes and even non-neural cells (J Cell Sci 2004, J Lipid Res 2007) store and can release neurotransmitter amino acids in a way resembling synaptic release, and that oligodendrocytes have NMDA type glutamate receptors (Nature 2005), together with findings that glutamate and other neuroactive substances can be co-released from nerve endings (Eur J Neurosci 2003, Molec Neurosci 2004, Cereb Cortex 2009a), including at the neuromuscular junction (Neuroscience 2007b), suggest novel ways of intercellular communication and potential drug targets.

Feng, P.; Zhao, H.; Chai, J.; Huang, L.; Wang, J. (2012) Expression and secretion of TNF - α In mouse taste buds: a novel function of a specific subset of type II taste cells.

This paper provides a new method for selective inactivation the NMDA receptors in specific cell types using a novel pharmacogenetic methodology.