Sentences with phrase «novel drug combination»

The novel drug combination allows the rapidly emerging cancer therapies called immune checkpoint inhibitors to be incorporated into a transplant patient's cancer treatment regimen.

Kenar D. Jhaveri, MD, and Richard Barnett, MD, Feinstein Institute for Medical Research scientists and Northwell Health Department of Internal Medicine nephrologists, published a Letter to the Editor in the New England Journal of Medicine, which profiles a novel drug combination with the potential to help prevent rejection of a donor kidney in transplant patients undergoing cancer treatment.

Not exact matches

«Researchers identify novel mechanism in combination drug therapy for acute myeloid leukemia, other cancers.»

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

The researchers believe that their combination of single - molecule fluorescence spectroscopy detection and their computational models offers a novel route for drug discovery.

However, VCU Massey Cancer Center and VCU Institute of Molecular Medicine (VIMM) scientists in the lab of Paul B. Fisher, M.Ph., Ph.D., are hoping to change that with a novel combination of an experimental drug and a common antibiotic that has shown promising results in preclinical experiments.

He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds of cancer cell lines, not just melanoma, and look for novel combinations that will benefit subsets of patients regardless of the particular type of tumor they have.

She has identified novel immune - modulating activities associated with targeted cancer drugs in preclinical models, and developed synergistic immunotherapy combinations.

To address the challenges of treating TBI and stroke, researchers from Florida Atlantic University's Charles E. Schmidt College of Medicine have developed and patented a novel approach combining three distinct classes of drugs to create a multi-drug combination therapy.

GigaGen is advancing a pipeline of first - in - class biotherapeutics, including novel oncology antibody drug combinations and the world's first recombinant polyclonal hyperimmune gammaglobulin.

He is using this knowledge to help design novel drugs and combination therapies to fight TB.

Equally important, by securing access to the best drugs from multiple companies, CRI is able to conduct clinical trials of novel combinations that might not otherwise be conducted.

The final aim is improving therapeutic effect and defining rationalized drug combinations with immune checkpoints and proprietary molecules developed by collaborators, including novel immunomodulatory approaches generated at our unit.

However, for the majority targeted therapies in development — and their combinations with current standard therapies — there are still no approved diagnostic tools to determine which patients are most likely to benefit from or be resistant to these novel agents or drug combinations.

Novel drug targets, or drug combinations that induce a synergistic response, would be of great benefit to patients.

My research efforts are focused on identifying novel combination therapies for breast cancer and the mechanisms that lead to drug resistance.

The National Institute on Drug Abuse awarded Dr. Matyas and his team a $ 5 million grant to research a novel combination heroin / HIV vaccine.

* Expertise in developing novel combination therapies, identifying drug resistance mechanisms, signaling pathways, tumor microenvironment.