Sentences with phrase «novel drug targets»

A better understanding of gut bacteria's role in multiple sclerosis may identify novel drug targets and pathways to improved health.

And the genetics is clearly pointing us toward valuable novel drug targets.

Cellular stress signals sent by macrophages amplify neuroinflammation, provide novel drug targets for MS therapy

«Now the challenge is to exploit this discovery in the development of novel drugs targeting EGFR mutants for cancer treatment in future.»

Research interests in his group include skin wound repair and novel drug targets in tumour metastasis.

Significance: The results will contribute to the understanding of the interaction of cellular structure, cellular organelle and cellular function and how this lead to neurodegeneration to provide novel drug targets for causative therapies.

«Identifying genetic mutations associated with disease risk is an effective way to better understand disease mechanisms, identify individuals at risk, and develop novel drug targets to treat the disease,» Dr. Peter added.

SEngine's strategy for discovering novel drug targets integrates the concept of «synthetic lethality» to tackle «undruggable» oncogenes and loss of tumor suppressor function.

«This new model speaks to how schizophrenia could arise before birth and identifies possible novel drug targets,» said Jerold Chun, a professor and member of the Dorris Neuroscience Center at TSRI who was senior author of the new study.

The findings in the paper, titled «Fatty Acid Binding Proteins are Intracellular Carriers for THC and CBD,» stem from the team's research that spans five years and includes their discoveries that showed anandamide levels were raised in rodent brains using novel drugs targeted to FABPs.

A new study exploring the NUDIX hydrolases in human cells provides attractive opportunities for expanding the use of this enzyme family as biomarkers and potential novel drug targets.

A detailed molecular understanding of the assembly, structure and function of the RNA replication spherules is essential to find novel drug targets to inhibit the replication and spread of positive - strand RNA viruses.

«Elucidation of essential pathways involved in the endosymbiosis... will allow for the identification of novel drug targets.»

They presented frontline research in various fields such as large - scale methods to identify novel drug targets, how to extract more information from microscopic images by the use of computational methods, as well as the movement and behavior of immune cells.

Over the next 18 months, deCODE and Pfizer will work together to analyse the genomes of patients to search for sequence variants that would be useful for understanding drug targets and discovering novel drug targets, that may ultimately lead to tools for patient stratification and companion diagnostics.

«We believe our results could eventually have a substantial impact on the development of treatments for retinal degenerative diseases, like retinitis pigmentosa and Leber's congenital amaurosis, by providing novel drug targets to prevent photoreceptor degeneration,» concludes Dr. Cayouette.

Together, these results support the use of the nuclear translocation of p38 and JNK as a novel drug target to treat various cancers and inflammation - induced diseases.

While the commercial potential might not be immediate, Duncan says the collaboration could yield concrete rewards for the companies, such as new R&D avenues from identification of novel drug targets.

Researchers at the La Jolla Institute for Allergy and Immunology, in collaboration with colleagues the University of California, San Diego, identified a novel drug target for the treatment of rheumatoid arthritis that focuses on the cells that are directly responsible for the cartilage damage in affected joints.

The discovery sheds new light on how Mtb metabolizes fatty acids and cholesterol, and also firmly establishes that LucA is required for full virulence of Mtb in vivo, and is therefore is a novel drug target in Mtb.

Given his training in developmental biology, Raman focused the team to seek a novel drug target on genes important to the development of model organisms — fruit flies (Drosophila) and yeast (Saccharomyces cerevisiae)-- rather than on oncogenes that transform a normal cell into a cancer cell.

It helps us understand the genetic basis of diversity and evolutions in organisms, leading to the insight understanding into how living things evolved through stressed environments to the pathogenesis of pathogens, including identification novel drug targets and development of novel drug candidates.

Findings from this work will identify a novel drug target for developing potential therapies for preventing cell death and preserving vision in dry AMD.

11/24/2008 UCSD Researchers Identify Potential New Drug Target for Chronic Leukemia Researchers at the University of California, San Diego (UCSD) and the Moores UCSD Cancer Center have discovered what could be a novel drug target for an often difficult - to - treat form of leukemia.

Elizabeth A. Winzeler of the University of California, San Diego, uses big data from whole - genome sequencing and genomics to identify novel drug targets and genes that contribute to pathogen drug resistance.