Novel drug therapies and novel indications of drug therapy, e.g. tyrosine kinase inhibitors in lung disease other than lung cancer, biological treatments for asthma, COPD, cystic fibrosis and interstitial lung disease.
The discovery provides an opportunity to pursue the development of
novel drug therapies to address obesity, type 2 diabetes and related metabolic diseases.
Not exact matches
The falling rate of cancer - related deaths is clearly an impressive achievement, and may be partially attributable to
drug makers» increased focus on developing
novel new
therapies to fight cancers.
On August 30, the U.S. Food and
Drug Administration approved a
novel gene
therapy for patients with a rare type of leukemia.
A spin - off from Queen's University 7 years ago, the
drug discovery and development company develops
novel cytochrome P450s to generate improved
therapies for skin diseases and cancer.
They can also be used to create
novel disease models from which new
drugs and
therapies can be developed.
«Researchers identify
novel mechanism in combination
drug therapy for acute myeloid leukemia, other cancers.»
He hopes that further studies may identify
novel approaches to immune - based cancer
therapy or reveal new
drug targets for inflammatory diseases.
This is important because it makes it possible to model almost any autoimmune disease, evaluate new
drug therapies, and even identify
novel targets in the emerging area of cancer immunotherapies.
While the findings suggest that
drugs targeting ASICs may one day lead to
novel therapies for anxiety disorders, Braga noted that «more research is needed to understand the roles that ASIC1a channels play in the brain.»
«Nanoparticles combine photodynamic and molecular
therapies against pancreatic cancer:
Novel drug - delivery system cuts off common treatment escape pathways in animal models.»
A number of these trials represent completely
novel classes of
therapy, such as employing fragments of RNA that interfere with problem genes or developing vaccines meant to quell
drug addiction.
«At Exeter we are already developing specific psychological
therapies, running clinical trials of
novel drug approaches and using - cutting edge genetic techniques to identify new targets for safe and effective
therapies and to allow us to use current treatments in a more focussed way.»
«There are currently no
drug therapies available that improve the very limited natural recovery from spinal cord injuries that patients experience,» said Lyn Jakeman, Ph.D., a program director at the NIH's National Institute of Neurological Disorders and Stroke, Bethesda, MD. «This is a great step towards identifying a
novel agent for helping people recover.»
Findings of a three - year clinical trial led by University of Cincinnati (UC) transplant researchers suggest that a
novel pre-operative
drug therapy reduces antibodies in kidney patients with greater success than with traditional methods, with the potential to increase the patients» candidacy for kidney transplantation and decrease the likelihood of organ rejection.
The
novel drug combination allows the rapidly emerging cancer
therapies called immune checkpoint inhibitors to be incorporated into a transplant patient's cancer treatment regimen.
Now, a new study suggests the
drug may also ease the symptoms of a genetic disease called hereditary hemorrhagic telangiectasia — a discovery that could guide researchers to
novel therapies for HHT and other vascular diseases.
Our findings may prove useful in the development of
novel therapies to efficiently reactivate latent HIV - 1, thus making it susceptible to current
drug therapies.
Where research uncovers possible mechanisms for disease, those working in
drug discovery can use these data to develop
novel diagnostic or monitoring tools, to develop
therapies that address the biological pathways concerned, or to develop companion diagnostics to ensure that new — or existing —
therapies are targeted at the correct subgroup of patients.
To address the challenges of treating TBI and stroke, researchers from Florida Atlantic University's Charles E. Schmidt College of Medicine have developed and patented a
novel approach combining three distinct classes of
drugs to create a multi-drug combination
therapy.
Founded in 2014, ImmunXperts provides immunogenicity and immune - oncology screening services, assessing all aspects of the immune responses in donors and patients, supporting its partners in the full development cycle of
novel drugs, biotherapeutics and stem cell
therapies.
Drug - repositioning opportunities for cancer
therapy:
novel molecular targets for known compounds.
This «humanized» mouse is susceptible to human liver infections and responds to human
drug treatments, providing a new way to test
novel therapies for debilitating human liver diseases and other diseases with liver involvement such as malaria.
Graber will also lead the development of the Comparative Models of Regeneration Database (RegenDB), a
novel bioinformatics resource supported by the National Institutes of Health (NIH) whose function is to integrate gene function across multiple animal, tissue and cell models in order to validate and inform the hypotheses needed for the discovery and development of regenerative medicine
drug therapies.
A bioengineer in the College of Engineering and Computer Science at Florida Atlantic University has received a $ 141,743 grant from the National Cancer Institute of the National Institutes of Health to develop a
novel biodegradable polymer stent that will be designed to prevent complications while at the same time serving as a
drug delivery system for esophageal cancer
therapy.
He is using this knowledge to help design
novel drugs and combination
therapies to fight TB.
Discoveries will be used to develop
novel diagnostic tools and
therapies for asthma and allergies, and to optimize patient benefit from existing
drugs
Discoveries will be used to develop
novel diagnostic tools and
therapies for asthma and allergies, and to optimize patient benefit from existing
drugs Reykjavik, ICELAND, July 17, 2002 — deCODE genetics (Nasdaq / Nasdaq Europe: DCGN) today announced that its scientists...
Epigenetic
Therapy A
novel two -
drug treatment targets epigenetic alterations that help give cancer cells their edge.
These studies support the idea that nutrient transporters can be exploited as potential
drug targets for cancer
therapy and usher us into a new era of
novel cancer therapeutics beyond kinase inhibitors and growth factor receptor blockers.
However, for the majority targeted
therapies in development — and their combinations with current standard
therapies — there are still no approved diagnostic tools to determine which patients are most likely to benefit from or be resistant to these
novel agents or
drug combinations.
The initiative aims to strengthen collaborations between SBP scientists, expand the range of scientific expertise and research capabilities and foster research alliances with industry partners working in neuroscience and
drug discovery research with the ultimate goal of translating
novel ideas and discoveries into
therapies that improve the life of patients suffering from brain diseases.
Cellular stress signals sent by macrophages amplify neuroinflammation, provide
novel drug targets for MS
therapy
Many of these strategies are used to then test
novel medications (including herbal preparations) or
therapies (including electroacupuncture) for
drug and alcohol abuse.
SEngine Precision Medicine, instead, is pursuing an innovative approach for the development of
novel targets and
drugs for cancer
therapy by using primary patient organoids initially derived for our diagnostic assay.
My research efforts are focused on identifying
novel combination
therapies for breast cancer and the mechanisms that lead to
drug resistance.
Drug screening in a zebrafish model of SCN1A mutation has identified lead compounds for development of
novel therapies.
Dr. Locke participated in the clinical trials that led to US Food and
Drug Administration approval of a
novel chimeric antigen receptor (CAR) T - cell
therapy called axicabtagene ciloleucel.
By identifying
novel molecular targets and potential new
drugs, this powerful technological structure will contribute significantly to groundbreaking research towards the development of new anti-cancer
therapies.
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Funded Study: Treatment of Feline Oral Squamous Cell Carcinoma — Evaluation of the
Novel Anti-Cancer
Drug, IB - DNQ, in Conjunction with Radiation
Therapy in Cats Diagnosed with Feline Oral Squamous Cell Carcinoma (FOSCC)
* Expertise in developing
novel combination
therapies, identifying
drug resistance mechanisms, signaling pathways, tumor microenvironment.