Sentences with phrase «novel gene functions»

We are exploring a number of different biological models to understand the origin of novel gene functions.

His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery / identification of novel gene function (s) and phenotypes using RNAi - mediated gene silencing or cDNA overexpression.

Not exact matches

This can disrupt the functioning of other genes and create novel proteins that have never been in the food supply and could create toxins and allergens in foods.

It has been estimated that 5 % to 10 % of infants who die from SIDS have novel mutations in the cardiac sodium or potassium channel genes that result in long QT syndrome as well as in other genes that regulate channel function.44 A recent report described important new molecular and functional evidence that implicates specific SCN5A (sodium channel gene) β subunits in SIDS pathogenesis.47 The identification of polymorphisms in genes pertinent to the embryologic origin of the autonomic nervous system in SIDS cases also lends support to the hypothesis that a genetic predisposition contributes to the etiology of SIDS.

«New innovative method for delivering genes into cells: Modification of cell physiological function with novel parallelized electroporation of mammalian cells by using electrostatic manipulation in a water - in - oil droplet.»

Monsanto's newest drought - tolerant product, Drought Guard, relies on a gene that creates a chaperone protein to coat a plant's RNA during stressful conditions and maintain the plant's normal cell functions, while Syngenta's hybrid contains novel drought - tolerant gene combinations.

«While it is completely plausible for a gene to lose or acquire novel biological functions, examples of such changes have predominantly been observed in the context of evolution,» Patkar says.

By identifying novel genes and molecular pathways involved in shaping a taste cell's function, these findings may someday allow scientists to treat taste disorders, characterize new taste qualities, or even fine - tune a person's taste perception to encourage healthier eating.

«While gene duplication and alternative splicing are typically invoked as major mechanisms underpinning protein neofunctionalization, this study suggests that the process of co-option should be re-evaluated as a potentially important method by which genes can acquire novel functions.»

That surprisingly low number suggested the evolution of new species was accompanied by rapid turnover of the venom genes, with old genes being abandoned and new ones with novel venom functions suddenly arising.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

Carlton devised a way of rapidly developing experimental mouse models, a staple of the translational field, to understand the function of novel genes.

This revolutionary technique is crucial for the study of the structure / function relationships of viral genes, for investigation of viral pathogenicity, and for development and manufacture of novel vaccines.

To accomplish this, I take a functional genomics approach to identify novel genes important for testes development and function.

We will explore the function of these genes in controlling synaptic homeostasis, develop novel imaging approaches to visualize homeostatic changes in real time, and systematically screen genes implicated in aging and longevity for roles in homeostatic plasticity.

Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia.

The next step based on these novel head and neck cancer discoveries, the scientists agree, is to tease out how the genes function in normal cells, whether they form the lining of the larynx, pharynx, or another anatomical site affected by head and neck cancer.

These results show that duplication of genes and genomes has been an important source of new genetic material that has subsequently evolved novel and more specialised functions.

In Axel's lab, Littman embraced a then - novel technique for transferring genes into mammalian cells to parse their functions.

Graber will also lead the development of the Comparative Models of Regeneration Database (RegenDB), a novel bioinformatics resource supported by the National Institutes of Health (NIH) whose function is to integrate gene function across multiple animal, tissue and cell models in order to validate and inform the hypotheses needed for the discovery and development of regenerative medicine drug therapies.

The recent Nature paper «High - throughput discovery of novel developmental phenotypes» describes the systematic high - throughput phenotyping screens used in the knock out mice and gives insight into a variety of gene function while a strong correlation was found between genes causing lethality in mice and genes causing diseases in humans, including cardiovascular defects, spina bifida, and metabolic disorders, among many others.

The goal is to produce a comprehensive «encyclopedia «of gene function, that will help identify causative factors of human diseases as well as novel targets for therapeutic intervention.

Fisher's exact test as implemented in R66 was run to test for enrichment or depletion of numbers of gene families for each molecular function category in the novel versus ancestral gene sets.

Currently, the Hu lab continues to analyze the functions of ER proteins in malignant progression of leukemia using novel mouse models, in which we selectively deleted genes that encode critical ER - resident proteins that support the growth and survival of leukemia.

These tumor suppressor genes are two of the most frequently altered genes in human cancer, and understanding how they function at the molecular level will both refine our fundamental understanding of this disease and suggest novel therapeutic approaches to treat it.

136/6: 15 Trans - ethnic meta - analysis reveals novel loci and effector genes for kidney function in diverse populations.

In addition to well - described genes, clusters often contain transcripts the function of which has not yet been associated with a specific biological process thus providing novel unexplored links to known molecular pathways.

This study identified 1,317 distinct genes found to be knocked out in humans; many of these genes (e.g., APOC3, PLA2G7, LPA) are being pursued as therapeutic targets, whereas many others are novel genes of unknown function.

Intriguingly, an identical homozygous mutation was identified in a human patient with recessive retinitis pigmentosa, the human equivalent of PRA, and established the novel retinal gene, PRCD, as an important gene for the maintenance of rod photoreceptor structure and function across species.