Sentences with phrase «novel gene identification»

There he pioneered the development of a novel gene identification technique of mapping by admixture linkage disequilibrium.

Not exact matches

Identification of novel polymorphisms in the glucokinase and glucose -6-phosphatase genes in infants who died suddenly and unexpectedly

It has been estimated that 5 % to 10 % of infants who die from SIDS have novel mutations in the cardiac sodium or potassium channel genes that result in long QT syndrome as well as in other genes that regulate channel function.44 A recent report described important new molecular and functional evidence that implicates specific SCN5A (sodium channel gene) β subunits in SIDS pathogenesis.47 The identification of polymorphisms in genes pertinent to the embryologic origin of the autonomic nervous system in SIDS cases also lends support to the hypothesis that a genetic predisposition contributes to the etiology of SIDS.

M. J. Bertram et al., Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor - like genes.

His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery / identification of novel gene function (s) and phenotypes using RNAi - mediated gene silencing or cDNA overexpression.

Collaborative research in Japan, under the guidance of the principle investigators from Fujita Health University and RIKEN, led to the identification of a novel risk gene (FADS1 and FADS2) for bipolar disorder via GWAS performed using samples collected in Japan (2,964 cases and 61,887 comparison subjects).

Conventional methods for identification of both RP mutations and novel RP genes involve the screening of DNA coding sequences.

Genome - scale metabolic models as platforms for identification of novel genes as antimicrobial drug targets — Bashir Sajo Mienda — Future Medicine

The transcriptomics and phosphoproteomics data generated by this project will allow the identification of novel host and parasite genes and pathways that play a key role during infection.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

Identification of novel Regulatory Factor X (RFX) target genes by Comparative Genomics in Drosophila species.

More recently, in a joint initiative with the BBMRI - LPC project (Biobanking and Biomolecular Resources Research Infrastructure — Large Prospective Cohorts) and the Wellcome Trust Sanger Institute, the CNAG - CRG launched a call to promote the use of sequencing technologies for the identification of novel causative variants and genes and to molecularly diagnose rare disease patients.

Identification of patients sharing variants in a given gene and having phenotypic features in common leads to greater certainty in the pathogenic nature of the gene and enables to the role of novel genes in development and disease to be defined.

He has made several important contributions in this area including identifying a new strain of CHIKV virus, identification of host cellular targets of HIV accessory genes, new novel DNA vaccine approaches for HIV, CHIKV, RSV, Dengue, MERS and Zika among others.

Identification of novel NRF2 - regulated genes by ChIPSeq: influence on retinoid X receptor alpha.

Identification of a novel sequence element in the common promoter region of human collagen type IV genes, involved in the regulation of divergent transcription

283/4: 30 Identification of RCBTB1 as novel disease gene for retinal ciliopathy.

Identification of novel mutations in the ENPP1 gene in eight patients with hypopigmented and hyperpigmented lesions and punctate palmoplantar keratosis led Radiocarbon dating is a popular dating method the general public is fairly familiar with.