Sentences with phrase «novel gene interactions»
Our BN analysis methods can be used to identify novel gene interactions and networks for advanced study of different biological networks and pathways.
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According to a new study recently published in the online edition of the journal Cancer Research, scientists pinpointed a novel interaction between the genes AEG - 1 and Akt2 that regulates the malignant characteristics of GBM.
«The database is a precious resource for the research community studying plant - microbe interactions as it is an unbiased way to identify potentially interesting genes involved in interaction with a plant — including many totally novel genes.
Hence, understanding the interrelationship between genetic markers and use of aspirin and NSAIDs, also known as gene × environment interactions, can help to identify population subgroups defined by genetic background that may preferentially benefit from chemopreventive use of these agents and offer novel insights into underlying mechanisms of carcinogenesis.
Our collaborative influenza projects: 1) characterizing the temporal and spatial evolutionary dynamics of the IAV and IBV circulating globally in humans and wild birds, 2) identifying the IAV genotypes circulating in pigs at county fairs (swine - human interface) to determine if fairs produce novel reassortants or enable zoonosis / reverse zoonosis, 3) determining if specific internal gene segment constellations enhance viral fitness, 4) detecting epistatic interactions between gene segments, and 5) assessing the impact of inter-hemispheric migration of viruses / gene segments.
A novel disrupter of telomere silencing 1 - like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)- activated gene expression.
The idea behind our work in bioinformatics is to build on existing methodologies regarding large - scale data analysis and to develop novel algorithms for processing and merging complex biological data from multiple sources such as gene expression data, sequence information, protein - to - protein interaction data, clinico - pathological data etc..
In this breed, the researchers found a novel mechanism of regulating blood sugar levels via an interaction of genes located on two different chromosomes.
70/3: 15 Chromosome interaction analysis of risk loci in related autoimmune diseases reveals complex, long - range promoter interactions implicating novel candidate genes.
To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.